Description

Hydrocortisone-21-Lysinate is a chemically modified derivative of the endogenous glucocorticoid hydrocortisone, where a lysine moiety is esterified at the 21-position. This modification is designed to enhance the compound's solubility and stability profile, making it a valuable intermediate in advanced pharmaceutical synthesis. It is primarily utilized by research institutions and manufacturers in the life sciences sector for the development of novel corticosteroid-based therapeutics and prodrugs. The compound offers a strategic building block for creating formulations with improved bioavailability and targeted delivery mechanisms.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of novel corticosteroid prodrugs and active pharmaceutical ingredients (APIs).
• Research & Development: Used in biochemical and pharmacological research to study steroid metabolism, receptor binding, and structure-activity relationships.
• Prodrug Development: Exploited for designing water-soluble derivatives of hydrocortisone to enhance drug delivery and patient compliance.
• Topical Formulation R&D: Investigated as a component in the development of advanced dermatological creams and ointments with modified release properties.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	Hydrocortisone-21-Lysinate
CAS No.	95924-98-4
Molecular Formula	C29H44N2O7
Molecular Weight	532.68 g/mol
Synonyms	Hydrocortisone 21-L-lysinate; 11β,17α,21-Trihydroxypregn-4-ene-3,20-dione 21-(N6-L-lysinate); Cortisol 21-lysinate; Lysinated Hydrocortisone; Hydrocortisone Lysine Ester; Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, 21-(N6-L-lysinate); (11β)-11,17,21-Trihydroxypregn-4-ene-3,20-dione 21-(N6-L-lysinate)
EINECS	Contact for details

Quality Control

Our Hydrocortisone-21-Lysinate is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification by spectroscopic methods (IR, NMR), purity assessment by HPLC, and control of related substances. A Certificate of Analysis (COA) detailing all test results and specifications is provided with every shipment to ensure traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.