Description

3-Nitro-4-(trifluoromethoxy)bromobenzene is a high-purity, multi-functional aromatic intermediate of significant importance in advanced organic synthesis. Its unique structure, featuring nitro, bromo, and trifluoromethoxy substituents, makes it a versatile building block for constructing complex molecules with tailored electronic and steric properties. This compound is primarily sought after by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring trifluoromethoxy or halogenated aromatic cores for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and insecticides, where the nitro and bromo groups serve as handles for further functionalization.
• Material Science Research: Serves as a monomer or building block for creating specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing substituents.
• Cross-Coupling Reactions: The bromine atom is an excellent site for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form biaryl or extended conjugated systems.
• Dye and Pigment Intermediate: Utilized in the synthesis of complex, high-performance dyes and pigments where the nitro group can be reduced to an amine for further diazotization and coupling.
• Chemical Research & Development: A valuable reagent for exploring new synthetic methodologies and constructing molecular libraries for high-throughput screening in drug discovery.

Basic Information

Product Name	3-Nitro-4-(trifluoromethoxy)bromobenzene
CAS No.	95668-20-5
Molecular Formula	C7H3BrF3NO3
Molecular Weight	285.99 g/mol
Synonyms	1-Bromo-2-nitro-4-(trifluoromethoxy)benzene; 4-Bromo-2-nitro-1-(trifluoromethoxy)benzene; Benzene, 1-bromo-2-nitro-4-(trifluoromethoxy)-; 2-Nitro-4-bromo-1-(trifluoromethoxy)benzene; 3-Nitro-4-bromo-1-(trifluoromethoxy)benzene; 4-Bromo-3-nitro-1-(trifluoromethoxy)benzene; 3-Nitro-4-bromo-alpha,alpha,α-trifluoroanisole
EINECS	Contact for details

Quality Control

Our 3-Nitro-4-(trifluoromethoxy)bromobenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent contamination and moisture absorption.

Specification

Item	Specification
Appearance	Light yellow to yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.