Description

S-Celiprolol is the single enantiomer of the β-adrenergic blocking agent celiprolol, specifically the (S)-(-)-enantiomer. This high-purity chiral intermediate is critical for the development and production of enantiomerically pure pharmaceuticals, where the specific stereochemistry is essential for targeted biological activity and reduced side-effect profiles. It is primarily required by advanced pharmaceutical R&D laboratories and fine chemical manufacturers engaged in the synthesis of next-generation cardiovascular therapeutics and for analytical reference standards.

Application

• Key chiral building block for the synthesis of enantiomerically pure celiprolol hydrochloride.
• Pharmaceutical reference standard for analytical method development, quality control, and regulatory submissions.
• Intermediate in research focused on cardiovascular drug discovery and structure-activity relationship (SAR) studies.
• Precursor for labeled compounds (e.g., deuterated or C14-labeled) used in pharmacokinetic and metabolic studies.
• Starting material for the preparation of novel β-blocker derivatives with improved selectivity.
• Used in academic and industrial research investigating the stereospecific effects of adrenergic receptor antagonists.

Basic Information

Product Name	S-Celiprolol
CAS No.	95586-73-5
Molecular Formula	C20H33N3O4
Molecular Weight	379.49 g/mol
Synonyms	(S)-(-)-Celiprolol; (S)-Celiprolol; (-)-Celiprolol; Levoceliprolol; UNII-9VXA2E1P15; (2S)-3-[3-Acetyl-4-[3-(tert-butylamino)-2-hydroxypropoxy]phenyl]-1,1-diethylurea; 1-(3-Acetyl-4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}phenyl)-3,3-diethylurea
EINECS	Contact for details

Quality Control

Our S-Celiprolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and enantiomeric excess meet exacting standards for pharmaceutical research and development. Certificates of Analysis (COA) detailing results for assay, chiral purity, related substances, and residual solvents are provided to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (Chiral HPLC)	≥99.0% (S-enantiomer)
Related Substances (HPLC)	Total impurities ≤1.5% Any single impurity ≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.