Description

Pregna-1,4-Diene-3,11,20-Trione, 17-(Acetyloxy)-21-Hydroxy- CAS NO 95440-71-4 is a high-purity steroid derivative, specifically a 17-acetoxy, 21-hydroxy derivative of prednisone, valued for its role as a critical pharmaceutical intermediate. This compound is essential for the synthesis and research of advanced corticosteroid-based active pharmaceutical ingredients (APIs). It is primarily required by pharmaceutical manufacturers and research institutions engaged in developing anti-inflammatory, immunosuppressive, and oncological therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the multi-step synthesis of potent corticosteroid drugs.
• Anti-inflammatory Drug Research: Used in R&D for developing new glucocorticoid receptor agonists with targeted efficacy.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method validation in pharmaceutical laboratories.
• Process Chemistry: Utilized in scaling up and optimizing manufacturing processes for steroid-based APIs under GMP conditions.
• Biochemical Research: Employed in studies investigating steroid hormone metabolism, receptor binding, and signaling pathways.
• Custom Synthesis: Acts as a starting material for the custom synthesis of novel steroid analogs with potential therapeutic applications.

Basic Information

Product Name	Pregna-1,4-Diene-3,11,20-Trione, 17-(Acetyloxy)-21-Hydroxy-
CAS No.	95440-71-4
Molecular Formula	C23H28O7
Molecular Weight	416.47 g/mol
Synonyms	21-Hydroxyprednisone 17-acetate; 17α,21-Dihydroxypregna-1,4-diene-3,11,20-trione 21-acetate; Prednisone 17-acetate, 21-hydroxy; 17-Acetoxy-21-hydroxyprednisone; 21-Hydroxy-17α-acetoxyprednisone; 17α-Acetoxy-21-hydroxypregna-1,4-diene-3,11,20-trione; 17-(Acetyloxy)-21-hydroxypregna-1,4-diene-3,11,20-trione
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,11,20-Trione, 17-(Acetyloxy)-21-Hydroxy- is manufactured and controlled to meet the stringent requirements for pharmaceutical intermediates. Production adheres to a robust Quality Management System. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, ensuring traceability and compliance with your internal specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.