Description

(S)-(-)-Carvedilol CAS NO 95094-00-1 is the single enantiomer of the non-selective β-blocker and α-1 blocker carvedilol, characterized by its specific stereochemistry. This high-purity chiral intermediate is critical for the research and development of enantiomerically pure pharmaceuticals, where the (S)-enantiomer is known to possess the primary β-adrenergic blocking activity. It is an essential building block for advanced pharmaceutical synthesis, serving the needs of research institutions, contract development and manufacturing organizations (CDMOs), and active pharmaceutical ingredient (API) producers focused on cardiovascular therapies.

Application

• Pharmaceutical Intermediate: Primary use as a key chiral synthon in the synthesis of enantiomerically pure carvedilol API.
• Cardiovascular Drug Research: Critical material for preclinical and clinical studies investigating the specific pharmacological profile of the (S)-enantiomer.
• Reference Standard: Serves as an analytical standard for method development, validation, and quality control in pharmaceutical testing laboratories.
• Process Development: Used in the development and optimization of asymmetric synthesis routes and purification processes.
• Metabolite Studies: Employed in the research of drug metabolism and pharmacokinetics (DMPK) for carvedilol.

Basic Information

Product Name	(S)-(-)-Carvedilol
CAS No.	95094-00-1
Molecular Formula	C24H26N2O4
Molecular Weight	406.48 g/mol
Synonyms	(S)-Carvedilol; (-)-Carvedilol; (S)-1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol; (S)-[3-(9H-Carbazol-4-yloxy)-2-hydroxypropyl][2-(2-methoxyphenoxy)ethyl]amine; Levocarvedilol (enantiomer); UNII-0K47UL67F2
EINECS	Contact for details

Quality Control

Our (S)-(-)-Carvedilol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets exacting standards for pharmaceutical research and development. A Certificate of Analysis (COA) detailing identity, purity, enantiomeric excess, and related substances is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Single Maximum Unknown Impurity	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.