Description

(R)-(+)-Carvedilol CAS NO 95093-99-5 is the pharmacologically active enantiomer of the non-selective β-blocker and α-1 blocker carvedilol. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure cardiovascular pharmaceuticals. It is primarily required by pharmaceutical R&D laboratories and API manufacturers focused on producing advanced, targeted therapies for hypertension and congestive heart failure.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key chiral building block in the synthesis of enantiopure carvedilol and its pharmaceutical salts.
• Cardiovascular Drug Research: Used in preclinical and clinical studies to investigate the specific pharmacological profile of the (R)-enantiomer.
• Process Development & Optimization: Serves as a reference standard and starting material for developing asymmetric synthesis and purification routes.
• Analytical Standard: Employed as a high-purity certified reference material (CRM) for HPLC, chiral chromatography, and spectroscopic method development and validation.
• Formulation Studies: Utilized in the development of novel drug delivery systems for improved bioavailability and patient compliance.

Basic Information

Product Name	(R)-(+)-Carvedilol
CAS No.	95093-99-5
Molecular Formula	C24H26N2O4
Molecular Weight	406.48 g/mol
Synonyms	(R)-Carvedilol; (+)-Carvedilol; (R)-(+)-1-(Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol; (2R)-1-(9H-Carbazol-4-yloxy)-3-[[2-(2-methoxyphenoxy)ethyl]amino]-2-propanol; UNII-0K47UL67F2; Dexcarvedilol (referring to the enantiomer)
EINECS	Contact for details

Quality Control

Our (R)-(+)-Carvedilol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay, identification, and impurity profiling via advanced techniques like HPLC and NMR to ensure compliance with pharmaceutical-grade standards. A detailed Certificate of Analysis (COA) specifying enantiomeric excess, chemical purity, and related substances is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.