Description

n-7-(2-(Nitrophenyldithio)Ethyl)Mitomycin C is a chemically modified derivative of the potent antitumor antibiotic Mitomycin C, designed for targeted drug delivery and advanced pharmaceutical research. This compound is engineered to act as a prodrug or a conjugate, where the nitrophenyldithioethyl moiety facilitates controlled release or specific targeting mechanisms. It is a critical intermediate and research chemical for scientists in oncology drug development, particularly for creating antibody-drug conjugates (ADCs) and exploring novel cancer therapeutics. The product's unique structure allows for the investigation of redox-sensitive drug activation pathways.

Application

• Antibody-Drug Conjugate (ADC) Payload: Serves as a potent cytotoxic warhead in the synthesis of targeted cancer therapies.
• Prodrug Development: Used in research to design and evaluate novel prodrug systems activated by specific cellular environments.
• Bioconjugation & Linker Chemistry: Acts as a key intermediate for attaching cytotoxic agents to targeting vectors like antibodies, peptides, or polymers.
• Oncology Research: Employed in in vitro and in vivo studies to investigate mechanisms of action, efficacy, and toxicity of next-generation chemotherapeutic agents.
• Biochemical Tool Compound: Utilized in studies exploring DNA alkylation, cross-linking, and redox biology in cancer cells.

Basic Information

Product Name	n-7-(2-(Nitrophenyldithio)Ethyl)Mitomycin C
CAS No.	95056-36-3
Molecular Formula	C22H24N4O8S2
Molecular Weight	536.58 g/mol
Synonyms	7-N-[2-[(2-Nitrophenyl)dithio]ethyl]mitomycin C; Mitomycin C S-(2-nitrophenyl) 2-ethyl dithio conjugate; 7-(2-((2-Nitrophenyl)disulfanyl)ethyl)mitomycin C; 7-N-(2-((2-Nitrophenyl)dithio)ethyl)mitomycin C; Nitrophenyldithioethyl Mitomycin C; ADC payload derivative of Mitomycin C; Redox-activated Mitomycin C prodrug
EINECS	Contact for details

Quality Control

Every batch of n-7-(2-(Nitrophenyldithio)Ethyl)Mitomycin C is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data to support research and development applications, ensuring identity, purity, and consistency. A detailed Certificate of Analysis (COA) is supplied with each shipment, reporting key parameters such as assay (HPLC), related substances, and confirmation of structure.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation and degradation. Allow the product to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term stability, store in the original packaging within a freezer dedicated for chemicals.

Specification

Item	Specification
Appearance	Reddish-brown to purple solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Consistent with molecular weight
Purity (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Water Content (KF)	≤ 1.0%
Solvent Residues (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.