Description

Tamibarotene is a synthetic retinoid derivative, specifically a benzoic acid derivative, with significant pharmacological activity. This compound is a potent and selective agonist for the retinoic acid receptor alpha (RARα), which is central to its mechanism of action in regulating cell differentiation and proliferation. It is primarily utilized in advanced pharmaceutical research and development, particularly for targeted therapeutic applications. Key industrial users include pharmaceutical manufacturers, biotechnology research firms, and academic institutions focused on oncology and dermatology.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of targeted cancer therapies, specifically for acute promyelocytic leukemia (APL).
• Biomedical Research: Critical tool for studying retinoid receptor signaling pathways, cell differentiation, and apoptosis in vitro and in vivo.
• Oncology Drug Development: Used in preclinical and clinical research for developing novel treatments for various cancers, including leukemia and solid tumors.
• Dermatology Research: Investigated for potential applications in treating skin disorders related to cell proliferation and differentiation.
• Chemical Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical laboratories.
• Intermediate for Advanced Synthesis: Used in the synthesis of more complex retinoid analogs and related bioactive molecules.

Basic Information

Product Name	Tamibarotene
CAS No.	94497-51-5
Molecular Formula	C₂₂H₂₅NO₃
Molecular Weight	351.44 g/mol
Synonyms	Am 80; Tamibarotene; 4-[(5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)carbamoyl]benzoic Acid; Benzoic acid, 4-[[(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)amino]carbonyl]-; AM-080; NSC 674495
EINECS	Contact for details

Quality Control

Our Tamibarotene is manufactured under strict quality management systems to ensure the highest standards of purity and consistency, suitable for pharmaceutical research and development. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing critical parameters such as assay, impurity profile, and identification. We adhere to relevant ICH guidelines and can support development with material meeting research-grade to GMP-grade standards as required. Certificates of Analysis (COA) are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under dry conditions to prevent degradation. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.