Description

Pregna-1,4-Diene-3,20-Dione, 9-Chloro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-, Disodium Salt, (11Beta,16Beta)- is a high-purity, water-soluble steroid derivative of significant pharmaceutical interest. This compound matters as a key synthetic intermediate or active pharmaceutical ingredient (API) for the development of novel corticosteroid-based therapeutics. Pharmaceutical R&D laboratories and fine chemical manufacturers need it for producing potent anti-inflammatory and immunosuppressive agents targeting a range of dermatological and systemic conditions.

Application

• Pharmaceutical Intermediate: Critical precursor in the multi-step synthesis of advanced corticosteroid drugs.
• Active Pharmaceutical Ingredient (API) Research: Serves as a core structural moiety for developing new glucocorticoid receptor modulators.
• Anti-inflammatory Drug Development: Used in R&D for creating topical and systemic treatments for conditions like psoriasis, eczema, and arthritis.
• Immunosuppressive Agent Synthesis: A building block for compounds used to manage autoimmune diseases and prevent organ transplant rejection.
• Biochemical Research: Utilized in studies investigating steroid hormone action, receptor binding, and metabolic pathways.
• Veterinary Pharmaceutical Manufacturing: Applied in the formulation of anti-inflammatory treatments for animals.

Basic Information

Item	Details
Product Name	Pregna-1,4-Diene-3,20-Dione, 9-Chloro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-, Disodium Salt, (11Beta,16Beta)-
CAS No.	94135-39-4
Molecular Formula	C22H27ClNa2O8P
Molecular Weight	539.85 g/mol
Synonyms	9-Chloro-11β,17-dihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate) disodium salt; Clocortolone 21-phosphate disodium salt; Clocortolone pivalate related compound; (11β,16β)-9-Chloro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione disodium salt; Disodium clocortolone phosphate; 9-Chloro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione cyclic 21-(hydrogen phosphate) disodium salt; Clocortolone phosphate disodium.
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 9-Chloro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-, Disodium Salt, (11Beta,16Beta)- is manufactured under strict quality systems. Products undergo rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and structural identity consistent with pharmaceutical-grade intermediates. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and other critical parameters is provided with each batch to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.