Description

Pregna-1,4-Diene-3,20-Dione, 21-(3-Carboxy-1-Oxopropoxy)-9-Fluoro-11,16,17-Trihydroxy-, Monosodium Salt, (11Beta,16Alpha)- is a high-purity synthetic corticosteroid derivative, specifically the monosodium salt of a succinate ester. This compound is a critical pharmaceutical intermediate valued for its potent anti-inflammatory and immunosuppressive properties. It is essential for research and development laboratories and manufacturers in the pharmaceutical industry, particularly those focused on advanced steroid-based therapeutics and novel drug delivery systems.

Application

• Pharmaceutical Intermediate: Primary use in the synthesis of potent corticosteroid active pharmaceutical ingredients (APIs).
• Research & Development: A key reference standard and building block in medicinal chemistry for developing new anti-inflammatory and immunosuppressive agents.
• Prodrug Development: The succinate ester form is often utilized to enhance water solubility and bioavailability for injectable formulations.
• Analytical Standard: Serves as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical testing laboratories.
• Biochemical Research: Used in studies investigating glucocorticoid receptor interactions and downstream metabolic pathways.

Basic Information

Item	Details
Product Name	Pregna-1,4-Diene-3,20-Dione, 21-(3-Carboxy-1-Oxopropoxy)-9-Fluoro-11,16,17-Trihydroxy-, Monosodium Salt, (11Beta,16Alpha)-
CAS No.	94135-37-2
Molecular Formula	C26H31FO9•Na
Molecular Weight	529.51 g/mol
Synonyms	9-Fluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-succinate monosodium salt; Prednisolone 21-hemisuccinate sodium salt; Sodium Prednisolone Succinate; Prednisolone Sodium Succinate (related derivative); 11β,16α,17,21-Tetrahydroxy-9-fluoro-1,4-pregnadiene-3,20-dione 21-(hydrogen succinate) sodium salt; Soluble Prednisolone derivative; Fluoroprednisolone succinate sodium salt
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 21-(3-Carboxy-1-Oxopropoxy)-9-Fluoro-11,16,17-Trihydroxy-, Monosodium Salt, (11Beta,16Alpha)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via IR and NMR, to ensure compliance with high-grade pharmaceutical intermediate standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.