Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Isonicotinate is a high-purity synthetic corticosteroid derivative, specifically an isonicotinate ester. This compound is a critical advanced pharmaceutical intermediate valued for its potent anti-inflammatory and immunosuppressive activity. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel topical and systemic corticosteroid medications.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent corticosteroid APIs (Active Pharmaceutical Ingredients).
• Anti-inflammatory Drug Research: Used in preclinical and clinical research for developing new treatments for dermatological conditions like eczema and psoriasis.
• Immunosuppressant Development: Serves as a precursor in creating drugs for managing autoimmune diseases and preventing organ transplant rejection.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development and validation.
• Biochemical Research: Utilized in studies investigating glucocorticoid receptor binding and steroid hormone pathways.
• Veterinary Medicine: Potential application in the formulation of anti-inflammatory treatments for animals.

Basic Information

Item	Details
Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Isonicotinate
CAS No.	94135-31-6
Molecular Formula	C₂₉H₃₄FNO₇
Molecular Weight	527.59 g/mol
Synonyms	Flunisolide 21-Isonicotinate; 9α-Fluoro-11β,16β,17,21-tetrahydroxypregna-1,4-diene-3,20-dione 21-(4-pyridinecarboxylate); 16β-Methyl-9α-fluoroprednisolone 21-isonicotinate; Flunisolide Isonicotinate Ester; 9α-Fluoro-16β-methylprednisolone 21-isonicotinate; 9-Fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-(4-pyridylcarboxylate)
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Beta-Methylpregna-1,4-Diene-3,20-Dione 21-Isonicotinate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) documenting HPLC purity, related substances, and other critical parameters are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Single Maximum Impurity	≤ 0.5%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.