Description

Pregna-1,4-Diene-3,20-Dione, 21-(3-Carboxy-1-Oxopropoxy)-9-Fluoro-11-Hydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-, Monosodium Salt, (11Beta,16Beta)- is a high-purity synthetic corticosteroid derivative, specifically the monosodium salt of a succinate ester. This compound is a critical pharmaceutical intermediate used in the synthesis of potent anti-inflammatory and immunosuppressive active pharmaceutical ingredients (APIs). It is essential for manufacturers in the pharmaceutical and fine chemical industries requiring reliable, high-quality building blocks for advanced steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Primary use as a key synthetic precursor in the manufacture of advanced corticosteroid drugs.
• Anti-inflammatory API Synthesis: Used in the production of potent glucocorticoid receptor agonists for treating conditions like severe allergies, asthma, and autoimmune disorders.
• Research & Development: Serves as a reference standard and starting material in medicinal chemistry research for novel steroid-based therapies.
• Veterinary Medicine: Potential application in the synthesis of anti-inflammatory treatments for animals.
• Fine Chemical Synthesis: Utilized in custom synthesis and process development for specialized steroid molecules.

Basic Information

Item	Details
Product Name	Pregna-1,4-Diene-3,20-Dione, 21-(3-Carboxy-1-Oxopropoxy)-9-Fluoro-11-Hydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-, Monosodium Salt, (11Beta,16Beta)-
CAS No.	94135-30-5
Molecular Formula	C28H33FO9Na
Molecular Weight	540.55 g/mol
Synonyms	9-Fluoro-11β,16β,17,21-tetrahydroxypregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-(hydrogen succinate) monosodium salt; Prednisolone 21-(hydrogen succinate) 16,17-acetonide 9-fluoro monosodium salt; 9-Fluoro-16α-methylprednisolone 21-hemisuccinate 16,17-acetonide sodium salt; Fluprednisolone 21-hemisuccinate acetonide sodium salt; (11β,16β)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione cyclic 16,17-acetal with acetone 21-(hydrogen succinate) monosodium salt; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione derivative is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical intermediates. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.