Description

Pregna-1,4-Diene-3,20-Dione, 9-Fluoro-11,17-Dihydroxy-21-(Phosphonooxy)-, Disodium Salt, (11Beta)- is a high-purity synthetic corticosteroid derivative, specifically a phosphorylated and disodium salt form of a fluorinated pregnadiene. This compound is valued for its enhanced water solubility and stability profile compared to its non-phosphorylated counterparts, making it a critical advanced intermediate in pharmaceutical synthesis. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the development and production of novel anti-inflammatory and immunosuppressive steroid-based therapeutics.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of advanced corticosteroid active pharmaceutical ingredients (APIs).
• Prodrug Development: Used in research for creating water-soluble prodrugs of potent glucocorticoids to improve bioavailability and delivery.
• Biochemical Research: Employed in studies investigating steroid receptor interactions, metabolism, and structure-activity relationships (SAR).
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.
• Veterinary Medicine: Potential application in the development of anti-inflammatory treatments for veterinary use.

Basic Information

Item	Details
Product Name	Pregna-1,4-Diene-3,20-Dione, 9-Fluoro-11,17-Dihydroxy-21-(Phosphonooxy)-, Disodium Salt, (11Beta)-
CAS No.	94088-00-3
Molecular Formula	C21H25FNa2O8P
Molecular Weight	500.37 g/mol
Synonyms	9-Fluoro-11β,17-dihydroxy-21-(phosphonooxy)pregna-1,4-diene-3,20-dione disodium salt; Fluorometholone Phosphate Disodium Salt; Fluorometholone 21-Phosphate Disodium; (11β)-9-Fluoro-11,17-dihydroxy-21-(phosphonooxy)pregna-1,4-diene-3,20-dione disodium salt; Disodium Fluorometholone Phosphate; 11β,17-Dihydroxy-9-fluoro-21-(phosphonooxy)pregna-1,4-diene-3,20-dione disodium salt
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 9-Fluoro-11,17-Dihydroxy-21-(Phosphonooxy)-, Disodium Salt, (11Beta)- is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by IR and NMR, and residual solvent analysis, to ensure it meets stringent specifications for pharmaceutical research and development. Certificates of Analysis (COA) documenting all test results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH guidelines
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.