Description

6Alpha,9-Difluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Isonicotinate is a high-purity synthetic corticosteroid derivative, specifically the 21-isonicotinate ester of a difluorinated glucocorticoid. This compound is a critical pharmaceutical intermediate valued for its potent anti-inflammatory and immunosuppressive activity, which is essential for advanced drug development. It is primarily required by research institutions and pharmaceutical manufacturers engaged in the synthesis of novel topical and systemic corticosteroid therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potent topical corticosteroids for dermatological conditions like eczema, psoriasis, and dermatitis.
• Active Pharmaceutical Ingredient (API) Development: Serves as a precursor in the research and production of advanced glucocorticoid receptor agonists.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research to develop new treatments for autoimmune disorders and severe allergic reactions.
• Veterinary Medicine: Employed in the formulation of anti-inflammatory and immunosuppressive treatments for animals.
• Reference Standard: Utilized as an analytical standard in quality control laboratories for method development and validation.

Basic Information

Product Name	6Alpha,9-Difluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Isonicotinate
CAS No.	94087-99-7
Molecular Formula	C₂₉H₃₃F₂NO₇
Molecular Weight	545.57 g/mol
Synonyms	Difluprednate Impurity; Difluprednate Related Compound; 21-Isonicotinoyloxy-6α,9-difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione; 6α,9α-Difluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-isonicotinate; 16α-Methyl-6α,9α-difluoroprednisolone 21-isonicotinate; DFD-21-Isonicotinate
EINECS	Contact for details

Quality Control

Our 6Alpha,9-Difluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Isonicotinate is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a low-humidity environment to prevent moisture absorption and degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.