Description

Pregna-1,4-Diene-3,20-Dione, 11-Hydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-21-(Phosphonooxy)-, Disodium Salt, (11Beta,16Alpha)- is a high-purity synthetic corticosteroid derivative, specifically a phosphorylated prodrug form of a potent glucocorticoid. This compound is of significant value for pharmaceutical research and development due to its targeted mechanism of action and enhanced solubility profile. It is primarily required by pharmaceutical manufacturers and advanced research institutions engaged in the development of novel anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: Critical raw material in the synthesis of advanced corticosteroid-based active pharmaceutical ingredients (APIs).
• Anti-inflammatory Drug Research: Used in preclinical and clinical research for developing new treatments for conditions like rheumatoid arthritis, psoriasis, and asthma.
• Immunosuppressive Therapy Development: Serves as a key compound in the formulation of drugs aimed at managing autoimmune diseases and preventing organ transplant rejection.
• Prodrug Formulation Studies: Utilized to study the pharmacokinetics and bioavailability of phosphorylated steroid prodrugs designed for improved delivery.
• Reference Standard: Acts as a certified reference material (CRM) for quality control and analytical method development in pharmaceutical laboratories.
• Biochemical Research: Employed in studies investigating glucocorticoid receptor interactions and downstream signaling pathways.

Basic Information

Product Name	Pregna-1,4-Diene-3,20-Dione, 11-Hydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-21-(Phosphonooxy)-, Disodium Salt, (11Beta,16Alpha)-
CAS No.	94087-98-6
Molecular Formula	C26H33Na2O10P
Molecular Weight	582.49 g/mol
Synonyms	Disodium Phosphate Prednisolone 16,17-Acetonide; 21-Phosphonatooxy-11β-hydroxy-16α,17α-isopropylidenedioxypregna-1,4-diene-3,20-dione Disodium Salt; Prednisolone 16,17-Acetonide 21-Phosphate Disodium Salt; 11β,16α-21-(Phosphonooxy)-11-hydroxy-16,17-[(1-methylethylidene)bis(oxy)]pregna-1,4-diene-3,20-dione Disodium Salt; Prednisolone Acetonide Phosphate Disodium; Steroid Phosphate Ester; Glucocorticoid Prodrug.
EINECS	Contact for details

Quality Control

Our Pregna-1,4-Diene-3,20-Dione, 11-Hydroxy-16,17-[(1-Methylethylidene)Bis(Oxy)]-21-(Phosphonooxy)-, Disodium Salt, (11Beta,16Alpha)- is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing including HPLC for purity, identification by IR and NMR spectroscopy, and residual solvent analysis to ensure compliance with pharmaceutical-grade standards. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.