Description

9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Acetylsalicylate is a high-purity synthetic corticosteroid derivative, specifically a salicylate ester prodrug of a fluorinated glucocorticoid. This compound is valued for its potent anti-inflammatory and immunosuppressive activity, making it a critical intermediate in advanced pharmaceutical research and development. It is primarily utilized by pharmaceutical manufacturers and research institutions focused on developing novel topical and systemic corticosteroid therapies.

Application

• Pharmaceutical Intermediate: Serves as a key building block in the synthesis of potent topical corticosteroids for dermatological conditions like eczema, psoriasis, and dermatitis.
• Anti-inflammatory Drug Research: Used in preclinical and clinical research to develop new glucocorticoid receptor agonists with optimized efficacy and safety profiles.
• Prodrug Development: Its acetylsalicylate ester moiety is studied for its potential to modify the pharmacokinetics, including absorption and hydrolysis rates, of the active glucocorticoid.
• Reference Standard: Employed as an analytical standard in quality control laboratories for the identification and quantification of active pharmaceutical ingredients (APIs) and related substances.
• Biochemical Research: Utilized in studies investigating the mechanisms of glucocorticoid action, gene regulation, and immune response modulation at the cellular level.

Basic Information

Product Name	9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Acetylsalicylate
CAS No.	94087-97-5
Molecular Formula	C31H37FO8
Molecular Weight	556.62 g/mol
Synonyms	Flumethasone 21-Acetylsalicylate; Flumethasone Pivalate Related Compound C (Acetylsalicylate); 9α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(2-acetoxybenzoate); Flumethasone Acetylsalicylate; 16α-Methyl-9α-fluoro-1,4-pregnadiene-11β,17,21-triol-3,20-dione 21-acetylsalicylate
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17,21-Trihydroxy-16Alpha-Methylpregna-1,4-Diene-3,20-Dione 21-Acetylsalicylate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical research and development. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.