Description

3-Chloro-2-Fluorobenzonitrile is a versatile fluorinated aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique halogen substitution pattern makes it a critical intermediate for constructing complex molecules with tailored properties. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in the development of kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and insecticides, where the fluorine and chlorine atoms enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals for display technologies.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and electron-transport materials.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, and Buchwald-Hartwig amination to create biaryl and other complex structures.
• Chemical Research & Development: A valuable reagent for medicinal chemistry, process chemistry, and exploring new synthetic methodologies in academic and industrial labs.

Basic Information

Item	Details
Product Name	3-Chloro-2-Fluorobenzonitrile
CAS No.	94087-40-8
Molecular Formula	C7H3ClFN
Molecular Weight	155.56 g/mol
Synonyms	2-Fluoro-3-chlorobenzonitrile; 3-Chloro-2-fluorobenzene carbonitrile; Benzonitrile, 3-chloro-2-fluoro-; 2-Fluoro-3-chlorobenzene nitrile; 3-Chloro-2-fluorophenyl cyanide; 94087-40-8; 3-Chloro-2-fluoro benzonitrile
EINECS	Contact for details

Quality Control

Our production of 3-Chloro-2-Fluorobenzonitrile adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity. Each lot is fully characterized and tested using advanced analytical techniques including GC, HPLC, NMR, and MS. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be kept in opaque packaging or amber glass.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.