Description

6Alpha-Fluoro-11Beta,17-Dihydroxy-16Alpha-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl 5-Oxo-L-Prolinate CAS NO 93940-69-3 is a high-purity synthetic corticosteroid derivative, specifically a prodrug of the potent anti-inflammatory agent fluocortolone. This compound is of critical importance for its role as a key pharmaceutical intermediate in the synthesis of advanced topical and systemic corticosteroid medications. It is primarily required by pharmaceutical R&D laboratories and manufacturing facilities focused on developing and producing specialized dermatological, ophthalmic, and anti-inflammatory treatments.

Application

• Pharmaceutical Intermediate: Primary use as a critical building block in the synthesis of fluocortolone and its related prodrugs and esters.
• Active Pharmaceutical Ingredient (API) Manufacturing: Serves as a direct precursor in GMP-compliant production lines for corticosteroid APIs.
• Dermatological Preparations: Research and development of creams, ointments, and lotions for treating eczema, psoriasis, and other inflammatory skin conditions.
• Ophthalmic Solutions: Formulation development for eye drops and suspensions targeting ocular inflammation and allergies.
• Systemic Corticosteroid Development: Used in the R&D of oral and injectable formulations for managing severe inflammatory and autoimmune disorders.
• Analytical Reference Standard: Serves as a high-purity certified reference material (CRM) for quality control and method validation in analytical laboratories.
• Preclinical & Clinical Research: Utilized in pharmacological studies to investigate potency, metabolism, and delivery mechanisms of modern corticosteroids.

Basic Information

Product Name	6Alpha-Fluoro-11Beta,17-Dihydroxy-16Alpha-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl 5-Oxo-L-Prolinate
CAS No.	93940-69-3
Molecular Formula	C28H36FNO7
Molecular Weight	517.59 g/mol
Synonyms	Fluocortolone Pivalate; Fluocortolone Trimethylacetate; 6α-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-pivalate; 6α-Fluoro-16α-methylprednisolone 21-pivalate; SH K 203; Zyma-203; Pivalone; Ultralan; Ultralanum; Fluocortolone 21-trimethylacetate
EINECS	Contact for details

Quality Control

Our 6Alpha-Fluoro-11Beta,17-Dihydroxy-16Alpha-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl 5-Oxo-L-Prolinate is manufactured under strict quality management systems. We offer material suitable for pharmaceutical R&D and GMP-grade intermediates, with specifications tailored to client requirements. All batches undergo rigorous analytical testing including HPLC, NMR, and MS for identity confirmation and purity verification. Certificates of Analysis (COA) detailing purity, related substances, and residual solvents are provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept tightly sealed in a dry environment and protected from exposure to light to maintain stability and purity. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤0.5%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.