Description

9-Fluoro-11Beta,17-Dihydroxy-16Beta-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl 5-Oxo-L-Prolinate CAS NO 93804-88-7 is a high-purity synthetic steroid derivative, specifically a prodrug of a potent glucocorticoid. This compound is of significant value in advanced pharmaceutical research and development due to its targeted biological activity. It is primarily required by pharmaceutical manufacturers and research institutions engaged in the development of novel anti-inflammatory and immunosuppressive therapies.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of advanced corticosteroid-based active pharmaceutical ingredients (APIs).
• Anti-inflammatory Drug Research: Used in preclinical and clinical research for developing new treatments for inflammatory conditions like dermatitis, arthritis, and asthma.
• Immunosuppressive Therapy Development: Serves as a precursor in creating compounds for managing autoimmune diseases and preventing organ transplant rejection.
• Metabolic & Endocrine Research: Employed in biochemical studies to investigate glucocorticoid receptor interactions and metabolic pathways.
• Reference Standard: Used as a certified reference material (CRM) in analytical laboratories for quality control and method validation.
• Prodrug Formulation Studies: Investigated for its pharmacokinetic properties to enhance drug delivery and bioavailability in final dosage forms.

Basic Information

Product Name	9-Fluoro-11Beta,17-Dihydroxy-16Beta-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl 5-Oxo-L-Prolinate
CAS No.	93804-88-7
Molecular Formula	C₂₈H₃₆FNO₇
Molecular Weight	517.59 g/mol
Synonyms	Fluticasone Propionate EP Impurity C; Fluticasone Propinate Related Compound C; Fluticasone Propionate Related Substance C; 9-Fluoro-11β,17-dihydroxy-16β-methyl-3,20-dioxopregna-1,4-dien-21-yl 5-oxo-L-prolinate; S-(Fluoromethyl) 6α,9-difluoro-11β,17-dihydroxy-16α-methyl-3-oxoandrosta-1,4-diene-17β-carbothioate prolinate derivative; L-Prolinic acid ester of fluticasone precursor; 93804-88-7
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,17-Dihydroxy-16Beta-Methyl-3,20-Dioxopregna-1,4-Dien-21-Yl 5-Oxo-L-Prolinate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation (IR, NMR), to ensure compliance with in-house specifications aligned with ICH guidelines. Certificates of Analysis (COA) detailing batch-specific results are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed in a dry environment and opened under conditions of low humidity to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Loss on Drying	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.