Description

S(-)-Atenolol CAS NO 93379-54-5 is the single enantiomer of the widely used β-blocker atenolol, characterized by its specific stereochemistry. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the study of stereospecific drug activity and metabolism. It is primarily utilized by pharmaceutical manufacturers and research institutions for developing enantiomerically pure cardiovascular drugs and for advanced analytical reference standards.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: As a key chiral building block for the production of enantiomerically pure β-adrenergic blocking agents.
• Pharmacological Research: For in-vitro and in-vivo studies to investigate the stereoselective effects, pharmacokinetics, and receptor binding affinity of atenolol enantiomers.
• Analytical Reference Standard: Used in HPLC, LC-MS, and chiral chromatography methods for method development, validation, and quality control testing of atenolol and related compounds.
• Process Development & Optimization: Serves as a critical standard in developing and scaling up asymmetric synthesis and purification processes within fine chemical manufacturing.
• Impurity Profiling: Essential for identifying and quantifying the (-)-enantiomer as a potential impurity in bulk (R,S)-atenolol or the (S)-enantiomer in final drug products.

Basic Information

Product Name	S(-)-Atenolol
CAS No.	93379-54-5
Molecular Formula	C14H22N2O3
Molecular Weight	266.34 g/mol
Synonyms	(S)-Atenolol; (-)-Atenolol; L-Atenolol; (S)-4-[2-Hydroxy-3-[(1-methylethyl)amino]propoxy]benzeneacetamide; Atenolol S-(-)-Enantiomer; (S)-(-)-Atenolol; UNII-50V9L2QR8C; CCRIS 9385
EINECS	Contact for details

Quality Control

Our S(-)-Atenolol is manufactured under strict quality management systems. Each batch is subjected to comprehensive analytical testing, including chiral purity assay and identification of related substances, to ensure it meets the stringent requirements for pharmaceutical research and development. A Certificate of Analysis (COA) detailing specifications such as enantiomeric excess (e.e.), chemical purity, and residual solvents is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% e.e.
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Related Substances (HPLC)	Individual impurity ≤0.5%; Total impurities ≤1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.