Description

Levobetaxolol is the pharmacologically active (S)-enantiomer of betaxolol, a selective β-1 adrenergic receptor antagonist. This high-purity chiral intermediate is critical for the synthesis of advanced ophthalmic and cardiovascular pharmaceutical formulations. It is primarily utilized by pharmaceutical R&D laboratories, API manufacturers, and fine chemical suppliers serving the global healthcare sector.

Application

• Active Pharmaceutical Ingredient (API) Synthesis: Key chiral building block for the production of Levobetaxolol Hydrochloride, the active component in ophthalmic solutions.
• Ophthalmic Drug Development: Used in R&D for medications targeting chronic open-angle glaucoma and ocular hypertension.
• Cardiovascular Research: Serves as a reference standard and intermediate in studies related to selective β-1 blockade.
• Chiral Resolution Studies: Employed as a pure enantiomer standard for analytical method development and quality control.
• Process Chemistry & Scale-Up: Integral intermediate in the commercial-scale manufacturing of enantiomerically pure β-blockers.
• Regulatory & Compliance Testing: Used as a high-purity certified reference material for stability testing and impurity profiling.

Basic Information

Product Name	Levobetaxolol
CAS No.	93221-48-8
Molecular Formula	C18H29NO3
Molecular Weight	307.43 g/mol
Synonyms	(S)-Betaxolol; (S)-1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)-2-propanol; (-)-Betaxolol; Levobetaxolol Base; (S)-(-)-Betaxolol; L-Betaxolol; UNII-8JQ5607IO5
EINECS	Contact for details

Quality Control

Our Levobetaxolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets stringent specifications for pharmaceutical intermediates. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support compliance with cGMP, ICH guidelines, and relevant pharmacopoeial standards.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccant or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.5%
Chiral Purity (Enantiomeric Excess)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.5%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.