Description

(11Beta,16Alpha)-9-Fluoro-21-(β-D-Galactopyranosyloxy)-11,17-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione is a high-purity, synthetic corticosteroid derivative with a galactopyranosyl moiety, representing a sophisticated active pharmaceutical ingredient (API) intermediate. Its primary value lies in enabling advanced pharmaceutical research and development, particularly for targeted drug delivery systems and novel anti-inflammatory or immunosuppressive therapies. This compound is essential for pharmaceutical manufacturers, biotechnology R&D laboratories, and academic institutions focused on endocrinology, steroid chemistry, and innovative therapeutic agent synthesis.

Application

• Pharmaceutical Intermediate: Critical starting material or intermediate in the multi-step synthesis of novel corticosteroid-based APIs.
• Drug Discovery & Development: Used in preclinical research for investigating structure-activity relationships (SAR) of fluorinated and glycosylated steroids.
• Targeted Therapy Research: The galactose moiety makes it a candidate for developing liver-targeted drug delivery systems due to asialoglycoprotein receptor (ASGPR) recognition.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for analytical method development, validation, and quality control in pharmaceutical analysis.
• Biochemical Research: Tool compound for studying glucocorticoid receptor interactions and metabolic pathways of modified steroids.
• Process Chemistry: Used in scaling up and optimizing synthetic routes for complex steroid molecules under current Good Manufacturing Practice (cGMP) guidelines.

Basic Information

Product Name	(11Beta,16Alpha)-9-Fluoro-21-(β-D-Galactopyranosyloxy)-11,17-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione
CAS No.	92901-23-0
Molecular Formula	C28H37FO9
Molecular Weight	536.59 g/mol
Synonyms	9-Fluoro-11β,17,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-galactoside; 21-O-β-D-Galactopyranosyl-9-fluoro-11β,17-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione; Galactosylated Fluocortolone Derivative; 9-Fluoro-16α-methylprednisolone 21-β-D-galactopyranoside; Fluocortolone Galactoside; Prednisolone Derivative Galactoside; 92901-23-0; 16α-Methyl-9-fluoro-δ1,4-pregnadiene-11β,17α,21-triol-3,20-dione 21-β-D-galactopyranoside
EINECS	Contact for details

Quality Control

Our (11Beta,16Alpha)-9-Fluoro-21-(β-D-Galactopyranosyloxy)-11,17-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione is manufactured and controlled under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identification by spectroscopic methods (NMR, IR, MS), to ensure it meets stringent specifications for pharmaceutical research. Certificates of Analysis (COA) detailing all test results are provided and can be tailored to support regulatory filings under ICH Q7 guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Optical Rotation	[α]20/D: Specific range provided on COA
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.