Description

2-(3-Fluoro-4-Iodophenyl)Acetonitrile is a versatile and high-value fluorinated and iodinated aromatic nitrile building block. This compound is critical for the synthesis of complex molecules, particularly in pharmaceutical research and advanced material science, where its unique halogenated structure enables precise molecular modifications. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), especially in kinase inhibitor and CNS drug discovery programs.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, leveraging the fluorine and iodine atoms for bioactivity and stability.
• Liquid Crystal & OLED Material Precursor: Serves as a building block for fluorinated and iodinated components in electronic display materials and organic light-emitting diodes.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Chemical Research & Development: Employed in academic and industrial labs for exploring new synthetic methodologies and creating custom fluorinated compounds.
• Positron Emission Tomography (PET) Tracer Development: The iodine-127 analog is a precursor for developing radioiodinated (e.g., I-124, I-131) diagnostic and therapeutic agents.

Basic Information

Product Name	2-(3-Fluoro-4-Iodophenyl)Acetonitrile
CAS No.	92676-16-9
Molecular Formula	C8H5FIN
Molecular Weight	261.04 g/mol
Synonyms	(3-Fluoro-4-iodophenyl)acetonitrile; 4-Iodo-3-fluorobenzyl cyanide; 2-(3-Fluoro-4-iodophenyl)ethanenitrile; 3-Fluoro-4-iodobenzyl cyanide; α-Cyano-3-fluoro-4-iodotoluene; 2-(4-Iodo-3-fluorophenyl)acetonitrile; 92676-16-9; 3-Fluoro-4-iodo-benzeneacetonitrile
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Fluoro-4-Iodophenyl)Acetonitrile is manufactured under strict quality management systems and undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as assay, impurity profile, and residual solvents. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flames. The container should be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.