Description

Saframycin G CAS NO 92569-02-3 is a potent member of the saframycin family of natural product antibiotics, characterized by its unique pyrroloquinoline quinone-like structure. This compound is valued for its significant biological activity, particularly as a DNA-binding agent and topoisomerase inhibitor, making it a crucial intermediate and reference standard in advanced research. It is primarily sought by pharmaceutical R&D laboratories and academic institutions engaged in the development of novel anticancer and antimicrobial therapeutics, as well as in mechanistic biochemical studies.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the synthesis and study of novel anticancer agents.
• Anticancer Agent Studies: Used in biochemical and cellular assays to investigate mechanisms of action related to DNA intercalation and topoisomerase I/II inhibition.
• Antimicrobial Research: Employed as a model compound in studies targeting drug-resistant bacterial strains, exploring structure-activity relationships within the saframycin class.
• Biochemical Tool Compound: Utilized in laboratory settings to study apoptosis induction and cell cycle arrest in various cancer cell lines.
• Academic & Institutional Research: Provides a high-purity chemical entity for universities and research institutes conducting fundamental research in medicinal chemistry and pharmacology.
• Process Development & Scale-up: Acts as a critical quality standard for companies developing synthetic routes or fermentation processes for saframycin analogs.

Basic Information

Product Name	Saframycin G
CAS No.	92569-02-3
Molecular Formula	C₂₉H₃₃N₃O₇
Molecular Weight	535.59 g/mol
Synonyms	Saframycin G; Antibiotic C-15003PH; C-15003PH; NSC 339638; (1S,13S,14R,32S,33S,36S)-33-[(2S)-2-Aminopropanoyl]oxy-14-ethyl-13,32-dihydroxy-7,22,28-trimethyl-2,5,10,19,24,30-hexaoxo-1,6,21,26,31-pentaazaoctacyclo[26.6.2.23,6.214,18.18,12.115,23.027,35.034,38]octatriaconta-3,8,10,12,15,17,23,27,29,34,36,38-dodecaene-36-carboxylic acid
EINECS	Contact for details

Quality Control

Our Saframycin G is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity determination, mass spectrometry for identity confirmation, and NMR for structural verification. A detailed Certificate of Analysis (COA) documenting identity, purity, and relevant physicochemical parameters is provided with every shipment to support your regulatory and research documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	Yellow to brownish-yellow powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.