Description

Amrubicinhydrochloride CAS NO 92470-31-0 is a hydrochloride salt form of the anthracycline antibiotic amrubicin, designed to enhance solubility and stability for pharmaceutical development. This compound is critical for research and manufacturing in oncology, serving as a key intermediate or active pharmaceutical ingredient (API) for targeted cancer therapeutics. It is primarily required by pharmaceutical companies, biotechnology research institutions, and contract development and manufacturing organizations (CDMOs) engaged in the synthesis of innovative chemotherapeutic agents.

Application

• Pharmaceutical API Synthesis: Serves as a critical intermediate or the final active pharmaceutical ingredient in the manufacture of injectable chemotherapeutic drugs.
• Oncology Research & Development: Used in preclinical and clinical studies to investigate the efficacy and mechanisms of anthracycline-based cancer treatments.
• Reference Standard: Employed as a high-purity analytical standard in quality control laboratories for method development, validation, and impurity profiling.
• Drug Formulation Development: Utilized in the development of stable parenteral formulations, including lyophilized powders or solution concentrates.
• Contract Manufacturing: Supplied to CDMOs for the production of clinical trial materials or commercial batches of oncology drugs.
• Metabolite Studies: Applied in pharmacological research to study the metabolism and pharmacokinetics of amrubicin and related compounds.

Basic Information

Product Name	Amrubicinhydrochloride
CAS No.	92470-31-0
Molecular Formula	C₂₅H₂₉NO₉ • HCl
Molecular Weight	532.0 g/mol (approx.)
Synonyms	Amrubicin Hydrochloride; (7S,9S)-9-Acetyl-9-amino-7-[(2-deoxy-β-D-erythro-pentopyranosyl)oxy]-7,8,9,10-tetrahydro-6,11-dihydroxy-5,12-naphthacenedione hydrochloride; SM-5887 Hydrochloride; Calsed Hydrochloride; Amrubicin HCl; 4-Demethoxy-13-dihydrodaunorubicin hydrochloride
EINECS	Contact for details

Quality Control

Our Amrubicinhydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including identification, purity assay, and impurity profiling via HPLC, to ensure it meets stringent specifications for pharmaceutical use. Certificates of Analysis (COA) are provided with each shipment, detailing compliance with relevant in-house or client-specific standards. We support development with research-grade through to GMP-grade materials as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment. For long-term storage, consider desiccants or inert atmosphere conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	Reddish-orange to orange powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time conforms to reference standard
Assay (HPLC)	≥98.0% (on anhydrous basis)
Water Content (KF)	≤5.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.