Description

(-)-R-Arotinolol is a specific enantiomer of the β-adrenergic receptor antagonist arotinolol, distinguished by its stereochemical purity. This compound is of significant value in pharmaceutical research and development, particularly for studying stereospecific drug-receptor interactions and metabolic pathways. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of enantiomerically pure active pharmaceutical ingredients (APIs) and advanced pharmacological studies.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiomerically pure β-blocker APIs.
• Pharmacological Research: Used in preclinical studies to investigate the stereoselective effects, potency, and metabolism of β-adrenergic antagonists.
• Reference Standard: Serves as a high-purity analytical standard for quality control and method development in chiral HPLC and other analytical techniques.
• Drug Discovery & Development: Employed in lead optimization and structure-activity relationship (SAR) studies for cardiovascular therapeutics.
• Metabolite Studies: Utilized in the identification and synthesis of specific drug metabolites for toxicological and pharmacokinetic profiling.

Basic Information

Product Name	(-)-R-Arotinolol
CAS No.	92075-58-6
Molecular Formula	C15H21N3O3S2
Molecular Weight	371.48 g/mol
Synonyms	(-)-R-Arotinolol; (R)-Arotinolol; R(-)-Arotinolol; 5-[2-[(2R)-3-[(2-Methyl-1H-indol-4-yl)oxy]-2-hydroxypropyl]amino]ethyl]-1,3-thiazolidine-2,4-dione; Arotinolol R-enantiomer; (R)-(-)-Arotinolol; UNII-6T3X2F2W7U (component R); (2R)-1-[(4-Methyl-1H-indol-5-yl)oxy]-3-[(4-oxo-2-thioxo-1,3-thiazolidin-5-yl)methylamino]propan-2-ol
EINECS	Contact for details

Quality Control

Our (-)-R-Arotinolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets exacting standards for research and development use. Certificates of Analysis (COA) with detailed chromatographic data are provided to guarantee identity, purity, and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% (R-enantiomer)
Related Substances (HPLC)	Total impurities ≤2.0%
Residual Solvents (GC)	Complies with ICH guidelines
Loss on Drying	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.