Description

Dextrobetaxolol CAS NO 91878-53-4 is the pharmacologically active enantiomer of betaxolol, a potent and selective β-1 adrenergic receptor antagonist. This high-purity chiral intermediate is critical for the development and manufacturing of enantiomerically pure cardiovascular and ophthalmic pharmaceuticals. It is essential for pharmaceutical R&D laboratories and API manufacturers requiring precise stereochemical control to ensure therapeutic efficacy and meet stringent regulatory standards for chiral drugs.

Application

• Active Pharmaceutical Ingredient (API) Intermediate: Key chiral building block in the synthesis of the β-blocker (S)-betaxolol hydrochloride.
• Ophthalmic Drug Development: Used in research and production of medications for treating glaucoma and ocular hypertension.
• Cardiovascular Drug Synthesis: Intermediate for antihypertensive and anti-arrhythmic agents targeting β-1 adrenergic receptors.
• Chiral Resolution Studies: Serves as a high-purity standard for analytical method development and enantiomeric excess (ee) determination.
• Pharmacology Research: Used in preclinical studies to investigate the specific biological activity of the (S)-enantiomer.
• Process Chemistry & Scale-Up: Employed in optimizing asymmetric synthesis routes for commercial pharmaceutical manufacturing.

Basic Information

Product Name	Dextrobetaxolol
CAS No.	91878-53-4
Molecular Formula	C18H29NO3
Molecular Weight	307.43 g/mol
Synonyms	(S)-Betaxolol; (S)-Betaxolol Base; (-)-Betaxolol; (S)-1-[4-[2-(Cyclopropylmethoxy)ethyl]phenoxy]-3-(isopropylamino)-2-propanol; Betaxolol Impurity C (S-enantiomer); Levobunolol Related Compound C; (S)-1-(4-(2-(Cyclopropylmethoxy)ethyl)phenoxy)-3-((1-methylethyl)amino)-2-propanol
EINECS	Contact for details

Quality Control

Our Dextrobetaxolol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric purity, to ensure it meets the high standards required for pharmaceutical development. Certificates of Analysis (COA) with detailed specifications are provided for every shipment, supporting compliance with cGMP and ICH guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.5%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Related Substances (HPLC)	Total impurities ≤1.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.