Description

(15R)-18,21-Didehydro-17-Demethoxy-12-o-Demethyl-18,21-Dideoxo-18,21-Dihydroxy-15-Methoxygeldanamycin CAS NO 91700-89-9 is a semi-synthetic derivative of the potent Hsp90 inhibitor geldanamycin, designed to enhance pharmacological properties and reduce toxicity. This compound is of significant interest for its potential in modulating heat shock protein 90 (Hsp90) activity, a key target in oncology and neurodegenerative disease research. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and contract research organizations (CROs) engaged in developing novel therapeutic agents.

Application

• Biochemical Research: As a critical tool compound for studying Hsp90 chaperone function, protein folding, and client protein degradation pathways.
• Oncology Drug Discovery: Serves as a lead structure or intermediate in the development of next-generation anti-cancer therapeutics targeting Hsp90-dependent oncogenic pathways.
• Neurodegenerative Disease Research: Investigated for its potential to mitigate protein aggregation in models of Alzheimer's, Parkinson's, and Huntington's diseases.
• Chemical Biology: Used in probe development to identify and validate novel Hsp90 interactions and downstream effects in cellular systems.
• Preclinical Development: Employed in pharmacokinetic, pharmacodynamic, and toxicology studies to establish proof-of-concept for geldanamycin analogs.

Basic Information

Product Name	(15R)-18,21-Didehydro-17-Demethoxy-12-o-Demethyl-18,21-Dideoxo-18,21-Dihydroxy-15-Methoxygeldanamycin
CAS No.	91700-89-9
Molecular Formula	C30H41NO8
Molecular Weight	543.65 g/mol
Synonyms	15-Methoxy-17-demethoxygeldanamycin derivative; 18,21-Didehydro-17-demethoxy-12-O-demethyl-18,21-dideoxo-18,21-dihydroxy-15-methoxygeldanamycin; 15-OMe-17-DMG; Modified Geldanamycin Analog; Benzoquinone ansamycin derivative; Hsp90 Inhibitor Derivative; 91700-89-9; (15R)-15-Methoxy-17-demethoxygeldanamycin
EINECS	Contact for details

Quality Control

Our (15R)-18,21-Didehydro-17-Demethoxy-12-o-Demethyl-18,21-Dideoxo-18,21-Dihydroxy-15-Methoxygeldanamycin is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization, including HPLC for purity, NMR and MS for structural confirmation, and residual solvent analysis. We provide a detailed Certificate of Analysis (COA) with every shipment, ensuring traceability and compliance with research-grade specifications. Our quality commitment supports reproducible and reliable results for your critical research and development work.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at -20°C or below under an inert atmosphere. The compound is light-sensitive and may be hygroscopic; allow the vial to equilibrate to room temperature in a desiccator before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.