Description

2-Propenenitrile,3-(2-Fluorophenyl)-,(Z)-(9Ci) is a specialized fluorinated acrylonitrile derivative of significant interest in advanced organic synthesis. This compound serves as a crucial chiral building block for constructing complex molecular architectures, particularly in the pharmaceutical and agrochemical sectors. Its unique stereochemistry and fluorinated aromatic moiety make it a valuable intermediate for researchers and process chemists developing active pharmaceutical ingredients (APIs), agrochemicals, and specialty materials. The CAS number for this compound is 91319-61-8.

Application

This fluorinated nitrile intermediate is designed for high-value synthetic applications, primarily in research and development as well as scale-up manufacturing.

• Pharmaceutical Intermediate: Key chiral precursor for the synthesis of fluorinated drug candidates, including kinase inhibitors and CNS-active compounds.
• Agrochemical Synthesis: Building block for novel herbicides and pesticides where the fluorine atom enhances biological activity and metabolic stability.
• Liquid Crystal & OLED Materials: Used in the development of fluorinated components for electronic displays and organic light-emitting diodes.
• Advanced Polymer Research: Monomer for specialty polymers with tailored optical, electronic, or surface properties.
• Chemical Biology Probes: Enables the creation of fluorinated probes for studying enzyme mechanisms and biological pathways.
• Asymmetric Catalysis Substrate: Serves as a test substrate in the development of new chiral catalysts and synthetic methodologies.

Basic Information

Item	Details
Product Name	2-Propenenitrile,3-(2-Fluorophenyl)-,(Z)-(9Ci)
CAS No.	91319-61-8
Molecular Formula	C9H6FN
Molecular Weight	147.15 g/mol
Synonyms	(Z)-3-(2-Fluorophenyl)acrylonitrile; (Z)-2-Fluorocinnamonitrile; (Z)-α-Fluoro-o-cyanostyrene; (Z)-3-(o-Fluorophenyl)-2-propenenitrile; (Z)-β-(2-Fluorophenyl)acrylonitrile; (Z)-2-Fluorobenzylideneacetonitrile; (Z)-1-Cyano-2-(2-fluorophenyl)ethene
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management protocols. Each batch is characterized using advanced analytical techniques including HPLC, GC, NMR, and chiral analysis to ensure high chemical and isomeric purity. Comprehensive Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are provided with every shipment. We support cGMP compliance for pharmaceutical applications and can tailor specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (typically 15-25°C). This compound may be light-sensitive and should be handled under an inert atmosphere for long-term stability. Keep away from strong oxidizing agents and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR / NMR)	Conforms to structure
Purity (HPLC / GC)	≥ 97.0%
Isomeric Purity (Z-isomer, HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.