Description

4-Demethoxy-10,10-Dimethyldaunomycin is a synthetic anthracycline derivative, a class of compounds renowned for their potent biological activity. This compound is of significant interest in pharmaceutical research and development due to its structural modifications, which are designed to explore and potentially enhance therapeutic efficacy while modulating associated properties. It serves as a critical intermediate or reference standard for researchers and manufacturers in the oncology and life sciences sectors, particularly those focused on novel chemotherapeutic agents.

Application

• Pharmaceutical Research Intermediate: Serves as a key synthetic precursor or building block in the development of novel anthracycline-based chemotherapeutic drugs.
• Biochemical Research: Used as a reference standard or probe in studies investigating DNA intercalation, topoisomerase II inhibition, and mechanisms of action of anticancer agents.
• Oncology Drug Discovery: Employed in high-throughput screening and structure-activity relationship (SAR) studies to develop new anticancer candidates with improved profiles.
• Analytical Reference Standard: Utilized in quality control laboratories for method development, validation, and quantification in HPLC, LC-MS, or other analytical techniques.
• Academic Research: Applied in university and institutional labs for fundamental research on cancer biology, drug resistance, and compound metabolism.

Basic Information

Product Name	4-Demethoxy-10,10-Dimethyldaunomycin
CAS No.	91003-74-6
Molecular Formula	C28H31NO9
Molecular Weight	525.55 g/mol
Synonyms	4-Demethoxy-10,10-dimethyldaunorubicin; 10,10-Dimethyl-4-demethoxydaunomycin; 4-Demethoxy-10,10-dimethyldaunorubicin hydrochloride (salt form); IDA-88; 4-DM-10,10-DM-DNR; Daunorubicin derivative, 4-demethoxy-10,10-dimethyl-; (8S,10S)-8-Acetyl-10-[(2S,4S,5S,6S)-4-amino-5-hydroxy-6-methyloxan-2-yl]oxy-6,8,11-trihydroxy-1-methoxy-9,10-dihydro-7H-tetracene-5,12-dione (IUPAC)
EINECS	Contact for details

Quality Control

Our 4-Demethoxy-10,10-Dimethyldaunomycin is manufactured under strict quality systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, identity confirmation by spectroscopic methods, and residual solvent analysis to ensure it meets high-purity standards suitable for research and development. Certificates of Analysis (COA) with detailed batch-specific data are available upon request to support your regulatory and quality assurance needs.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at a controlled room temperature (15-25°C) to minimize oxidation and degradation. The container should be kept in a cool, dry, and well-ventilated area, away from incompatible materials.

Specification

Item	Specification
Appearance	Orange to red powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.