Description

4-(Difluoromethoxy)Benzonitrile is a versatile fluorinated aromatic nitrile building block of significant interest in advanced organic synthesis. Its value lies in the unique reactivity imparted by the difluoromethoxy group, which can serve as a bioisostere or impart desirable physicochemical properties to target molecules. This compound is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS, metabolic, and inflammatory diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy moiety can enhance biological activity and environmental stability.
• Liquid Crystal Materials: Serves as a precursor in the synthesis of fluorinated liquid crystals for display technologies, leveraging its polarizability and molecular shape.
• Polymer Science: Employed as a monomer or modifier in the synthesis of specialty polymers, including high-performance engineering plastics and coatings with specific chemical resistance.
• Organic Electronics: Acts as a building block for electron-transport materials, semiconductors, and other components used in OLEDs and organic photovoltaic cells.
• Chemical Research: A valuable reagent for method development in fluorination chemistry and cross-coupling reactions, enabling the exploration of new synthetic pathways.

Basic Information

Product Name	4-(Difluoromethoxy)Benzonitrile
CAS No.	90446-25-6
Molecular Formula	C8H5F2NO
Molecular Weight	169.13 g/mol
Synonyms	p-(Difluoromethoxy)benzonitrile; 4-(Difluoromethoxy)phenyl cyanide; Benzonitrile, 4-(difluoromethoxy)-; 1-Cyano-4-(difluoromethoxy)benzene; α,α-Difluoro-p-cyanophenyl methyl ether; DFMB; (4-Cyanophenoxy)difluoromethane
EINECS	Contact for details

Quality Control

Our 4-(Difluoromethoxy)Benzonitrile is produced under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment ensures the material meets the high standards required for research and cGMP manufacturing applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly closed in a dry and well-ventilated place.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.