Description

Bicalutamide CAS NO 90357-06-5 is a non-steroidal anti-androgen pharmaceutical compound used in the treatment of prostate cancer. It functions as a selective antagonist of the androgen receptor, blocking the effects of hormones like testosterone that can fuel cancer growth. This active pharmaceutical ingredient (API) is essential for manufacturers developing hormone therapy medications for oncology applications.

Application

• Pharmaceutical API: Primary use as the active ingredient in anti-androgen medications for the treatment of advanced prostate cancer.
• Hormone Therapy Formulations: Used in combination therapy regimens, often paired with a gonadotropin-releasing hormone (GnRH) analog.
• Oncology Research: Serves as a critical reference standard and tool compound in preclinical studies investigating androgen receptor pathways and cancer biology.
• Generic Drug Manufacturing: A key component for pharmaceutical companies producing generic versions of branded prostate cancer therapies.
• Dosage Form Development: Incorporated into solid oral dosage forms, most commonly film-coated tablets.

Basic Information

Product Name	Bicalutamide
CAS No.	90357-06-5
Molecular Formula	C18H14F4N2O4S
Molecular Weight	430.37 g/mol
Synonyms	Bicalutamide; Casodex; ICI 176,334; 4'-Cyano-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methyl-3'-(trifluoromethyl)propionanilide; (RS)-N-[4-Cyano-3-(trifluoromethyl)phenyl]-3-[(4-fluorophenyl)sulfonyl]-2-hydroxy-2-methylpropanamide; ICI-176334; ZD-176334
EINECS	Contact for details

Quality Control

Our Bicalutamide is manufactured under strict quality management systems to ensure it meets the stringent requirements for pharmaceutical active ingredients. Quality is assured through comprehensive analytical testing, including identity, purity, and impurity profile confirmation against relevant pharmacopeial standards (e.g., USP, EP). A Certificate of Analysis (COA) documenting all test results is provided with each batch.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to protect the product from moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms
Assay (HPLC)	98.0% - 102.0%
Related Substances (HPLC)	Total impurities ≤ 1.0% Any individual impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH Q3C
Heavy Metals	≤ 20 ppm
Loss on Drying	≤ 0.5%
Sulfated Ash	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.