Description

Nebivolol CAS NO 9920-09-6 is a highly selective β-1 adrenergic receptor blocker, recognized for its unique vasodilatory properties. This active pharmaceutical ingredient (API) is critical for the development and manufacture of cardiovascular therapeutics. It is primarily required by pharmaceutical companies and research institutions engaged in the production of antihypertensive and heart failure medications.

Application

• Pharmaceutical API: Primary use as the active ingredient in finished dosage forms for the treatment of hypertension.
• Cardiovascular Research: Used in preclinical and clinical studies to investigate its hemodynamic effects and receptor selectivity.
• Generic Drug Manufacturing: Serves as a key component for companies producing generic versions of nebivolol-based medications.
• Formulation Development: Employed in R&D labs for developing new drug delivery systems, such as controlled-release tablets.
• Reference Standard: Utilized as a high-purity analytical standard in quality control laboratories for method development and validation.
• Combination Therapies: Investigated for use in fixed-dose combination products with other antihypertensive agents.

Basic Information

Product Name	Nebivolol
CAS No.	9920-09-6
Molecular Formula	C22H25F2NO4
Molecular Weight	405.44 g/mol
Synonyms	Nebivolol Hydrochloride; Bystolic; R 65-824; (1RS,1'RS)-1,1'-[(2RS,2'SR)-Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]-2,2'-iminodiethanol; 1,1'-[Bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl)]-2,2'-iminodiethanol; DL-Nebivolol; (±)-Nebivolol
EINECS	Contact for details

Quality Control

Our Nebivolol is manufactured under strict quality management systems. It undergoes comprehensive analytical testing, including HPLC for assay and related substances, residual solvent analysis, and identification by IR and NMR, to ensure it meets high-purity pharmacopeial standards (e.g., USP, EP). A detailed Certificate of Analysis (COA) is provided with each batch to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Individual impurity: NMT 0.5% Total impurities: NMT 2.0%
Water (KF)	NMT 1.0%
Residue on Ignition	NMT 0.1%
Heavy Metals	NMT 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.