Description

Bleomycin-B4 CAS NO 9060-11-1 is a specific glycopeptide antibiotic variant belonging to the bleomycin family, a group of cytostatic agents. This compound is valued for its role as a critical reference standard and active pharmaceutical ingredient (API) in oncological research and development. It is primarily required by pharmaceutical manufacturers, biotechnology research institutions, and academic laboratories focused on developing and testing novel chemotherapeutic agents and studying DNA cleavage mechanisms.

Application

• Pharmaceutical Reference Standard: Used as a high-purity calibrant in analytical methods (HPLC, LC-MS) for quality control of bleomycin-based drug products.
• Oncology Research: Serves as a key biochemical tool for studying the mechanism of action of bleomycins, including DNA strand scission and inhibition of tumor cell proliferation.
• Active Pharmaceutical Ingredient (API): A critical component in the formulation of specific anti-cancer chemotherapeutic preparations.
• Biochemical Studies: Employed in research to investigate the effects of glycopeptide antibiotics on cellular processes and their interaction with metal ions like iron.
• Preclinical Development: Utilized in in vitro and in vivo studies to evaluate the efficacy and toxicity profiles of bleomycin variants.

Basic Information

Item	Details
Product Name	Bleomycin-B4
CAS No.	9060-11-1
Molecular Formula	C55H84N17O21S2+
Molecular Weight	Approx. 1415.5 g/mol (as free base)
Synonyms	Bleomycin B4; Bleomycin B-4; Bleomycin B 4; Bleomycin A2/B2; NSC-125066; Antibiotic Bleomycin B4; Blenoxane component (related); Bleomycin sulfate (complex); Glycopeptide antibiotic B4; Bleomycin family antibiotic
EINECS	Contact for details

Quality Control

Our Bleomycin-B4 is manufactured under strict quality systems to ensure it meets the exacting standards required for pharmaceutical research and development. Each batch is subjected to comprehensive analytical testing, including identity confirmation, purity assay, and impurity profiling via advanced chromatographic techniques. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to guarantee traceability and compliance with your quality protocols.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature or as specified on the label. Due to its hygroscopic (moisture-sensitive) nature, the container should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0% (on anhydrous basis)
Water Content (KF)	≤ 5.0 %
Related Substances (HPLC)	Total impurities ≤ 3.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C
Bacterial Endotoxins	< 5.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.