Description

Bleomycin B2 CAS NO 9060-10-0 is a glycopeptide antibiotic and a key component of the bleomycin complex, a clinically significant antitumor agent. Its primary value lies in its ability to induce single- and double-strand breaks in DNA, making it a critical active pharmaceutical ingredient (API) for research and pharmaceutical manufacturing. This compound is essential for pharmaceutical companies, research institutions, and academic laboratories focused on oncology drug development, biochemical research, and the study of DNA-damaging agents.

Application

• Pharmaceutical Active Ingredient (API): Core component in the formulation of injectable chemotherapeutic agents for treating various cancers, including Hodgkin's lymphoma, testicular cancer, and squamous cell carcinomas.
• Biochemical & Cancer Research: Used as a standard and tool compound in laboratories to study mechanisms of DNA cleavage, cell cycle arrest, and apoptosis in cancer cell lines.
• Reference Standard: Serves as a high-purity chromatographic reference standard for quality control and analytical method development in pharmaceutical QC/QA laboratories.
• Preclinical Studies: Employed in in vitro and in vivo studies to evaluate antitumor efficacy and understand the pharmacokinetics and pharmacodynamics of bleomycin-type drugs.
• Mechanistic Probe: Utilized to investigate the role of metal ions (e.g., iron) in mediating oxidative DNA damage and to explore combination therapies.

Basic Information

Product Name	Bleomycin B2
CAS No.	9060-10-0
Molecular Formula	C55H84N17O21S3
Molecular Weight	1415.56 g/mol
Synonyms	Bleomycin B2; Bleomycin A2/B2 mixture component; NSC-125066; Bleomycin sulfate component B2; Antibiotic Bleomycin B2; Blenoxane component B2; Bleomycin (sulfate) B2; 5'-{[(1S)-1-Phenylethyl]carbamoyl}-3'-O-{3-O-carbamoyl-5-O-{3-[(2-{[(2S,3S,4R,5S,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxy}ethyl)carbamoyl]propyl}-2-O-{3-[(carbamoylmethyl)carbamoyl]propyl}-α-L-talopyranosyl}pyromycin
EINECS	Contact for details

Quality Control

Our Bleomycin B2 is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets stringent specifications suitable for research and pharmaceutical use. Certificates of Analysis (COA) detailing purity, impurities, and other critical parameters are provided with every shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive) and should be kept in a dry environment. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Single Maximum Unknown Impurity	≤ 1.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.