Description

9-Fluoro-11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate) is a high-purity synthetic corticosteroid phosphate ester, a key pharmaceutical intermediate of significant commercial and research value. Its primary importance lies in its role as a precursor in the synthesis of potent anti-inflammatory and immunosuppressive steroid drugs. This compound is essential for manufacturers and research institutions in the pharmaceutical and biotechnology sectors focused on developing advanced corticosteroid therapies.

Application

• Pharmaceutical Intermediate: Critical precursor for the synthesis of advanced corticosteroid APIs (Active Pharmaceutical Ingredients) such as dexamethasone phosphate and related analogs.
• Anti-inflammatory Drug Research: Used in R&D for developing new topical and systemic corticosteroid formulations with enhanced efficacy and bioavailability.
• Immunosuppressive Therapy Development: A key building block in creating compounds for managing autoimmune diseases and preventing organ transplant rejection.
• Reference Standard: Serves as a high-purity analytical standard for quality control and regulatory testing in pharmaceutical manufacturing.
• Process Chemistry: Employed in process development and scale-up studies for optimizing steroid synthesis pathways.
• Biochemical Research: Used in academic and industrial laboratories to study glucocorticoid receptor interactions and metabolic pathways.

Basic Information

Product Name	9-Fluoro-11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate)
CAS No.	989-96-8
Molecular Formula	C24H32FO8P
Molecular Weight	498.48 g/mol
Synonyms	Dexamethasone 21-Phosphate; Dexamethasone Phosphate; 9α-Fluoro-16α-methylprednisolone 21-phosphate; 9α-Fluoro-11β,17α,21-trihydroxy-16α-methylpregna-1,4-diene-3,20-dione 21-(dihydrogen phosphate); Dexamethasone 21-(Dihydrogen Phosphate); 16α-Methyl-9α-fluoroprednisolone 21-phosphate; Dexamethasone 21-Phosphate Ester; NSC-34521
EINECS	Contact for details

Quality Control

Our 9-Fluoro-11Beta,21-Dihydroxy-16Alpha,17-(Isopropylidenedioxy)Pregna-1,4-Diene-3,20-Dione 21-(Dihydrogen Phosphate) is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing to ensure it meets stringent specifications for identity, purity, and impurity profiles, suitable for pharmaceutical intermediate applications. Certificates of Analysis (COA) documenting comprehensive test results are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 2.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.