Description

Betamethasone 21-Acetate is a synthetic glucocorticoid corticosteroid, specifically the 21-acetate ester derivative of betamethasone. This compound is a critical pharmaceutical intermediate and active pharmaceutical ingredient (API) valued for its potent anti-inflammatory and immunosuppressive properties. It is primarily utilized by pharmaceutical manufacturers and research institutions in the development and production of topical and injectable corticosteroid formulations for treating various dermatological, ophthalmic, and rheumatic conditions.

Application

• Pharmaceutical API: Core active ingredient in the synthesis of finished corticosteroid drugs.
• Topical Formulations: Used in creams, ointments, and lotions for treating eczema, psoriasis, and dermatitis.
• Injectable Solutions: Manufacture of sterile suspensions for intra-articular or soft tissue injections to reduce inflammation.
• Ophthalmic Preparations: Key component in eye drops and ointments for managing ocular inflammation.
• Veterinary Medicine: Anti-inflammatory agent in topical and injectable products for animals.
• Research & Development: Reference standard and building block in pharmacological and metabolic studies.
• Combination Therapies: Used in combination with antimicrobial agents in compounded medications.

Basic Information

Product Name	Betamethasone 21-Acetate
CAS No.	987-24-6
Molecular Formula	C24H31FO6
Molecular Weight	434.50 g/mol
Synonyms	9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione 21-acetate; Betamethasone Acetate; Flubenisolone 21-Acetate; 9α-Fluoro-16β-methylprednisolone 21-Acetate; Betamethasone 21-Acetate Ester; Betamethasone Acetate (USP); NSC-39471
EINECS	213-585-7

Quality Control

Our Betamethasone 21-Acetate is manufactured under strict quality management systems. Each batch is tested to meet high-purity standards, including compliance with USP/EP monograph requirements where applicable. Comprehensive testing covers identity, assay, related substances, residual solvents, and specific tests. A Certificate of Analysis (COA) documenting all test results is provided with every shipment to ensure full traceability and regulatory support for our customers.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept in a dry environment to prevent degradation. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to almost white crystalline powder
Identification (IR)	Conforms
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Specific Rotation	+100° to +107° (c=1 in dioxane)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.