Description

Pregn-4-Ene-3,20-Dione, 21-Chloro-9-Fluoro-11,16,17-Trihydroxy-, (11β,16α)- is a high-purity synthetic steroid derivative, also known as 21-Chloro-9α-fluoro-11β,16α,17α-trihydroxypregn-4-ene-3,20-dione. This compound serves as a critical pharmaceutical intermediate in the synthesis of potent corticosteroid drugs, valued for its specific structural modifications that confer enhanced biological activity. It is primarily required by pharmaceutical R&D laboratories and manufacturers engaged in the production of advanced anti-inflammatory and immunosuppressive medications.

Application

• Pharmaceutical Intermediate: Key starting material or intermediate in the multi-step synthesis of high-potency topical and systemic corticosteroids.
• Active Pharmaceutical Ingredient (API) Development: Used in research and development for creating new steroid-based therapeutics with modified pharmacokinetic profiles.
• Biochemical Research: Serves as a reference standard or probe in steroid receptor binding studies and metabolic pathway research.
• Veterinary Medicine: Potential use in the development of anti-inflammatory treatments for animals.
• Process Chemistry: Utilized in scaling up and optimizing manufacturing processes for complex steroid molecules.

Basic Information

Item	Detail
Product Name	Pregn-4-Ene-3,20-Dione, 21-Chloro-9-Fluoro-11,16,17-Trihydroxy-, (11β,16α)-
CAS No.	982-91-2
Molecular Formula	C21H26ClFO5
Molecular Weight	412.88 g/mol
Synonyms	21-Chloro-9α-fluoro-11β,16α,17α-trihydroxypregn-4-ene-3,20-dione; 9α-Fluoro-21-chloro-11β,16α,17α-trihydroxypregn-4-ene-3,20-dione; 21-Chloro-9α-fluoro-16α-hydroxyprednisolone; Fluprednisolone 21-Chloride; 21-Chloro-9-fluoro-11β,16α,17α-trihydroxypregn-4-ene-3,20-dione; 982-91-2; NSC 47439
EINECS	Contact for details

Quality Control

Our Pregn-4-Ene-3,20-Dione, 21-Chloro-9-Fluoro-11,16,17-Trihydroxy-, (11β,16α)- is manufactured under strict quality systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and IR spectroscopy, to ensure high chemical purity and structural identity. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles suitable for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.