Description

9β,11β-Epoxy-17,21-Dihydroxy-16β-Methylpregna-1,4-Diene-3,20-Dione is a high-purity synthetic steroid intermediate of significant importance in advanced pharmaceutical manufacturing. Its complex, functionalized structure makes it a critical precursor for the synthesis of potent corticosteroid APIs, where precise stereochemistry is paramount for biological activity. This compound is essential for R&D and production teams in the pharmaceutical and fine chemical industries seeking reliable, high-quality building blocks for complex organic synthesis.

Application

• Pharmaceutical Intermediate: A key starting material or intermediate in the multi-step synthesis of potent glucocorticoid and anti-inflammatory corticosteroid drugs.
• Active Pharmaceutical Ingredient (API) Synthesis: Used in the production of specific corticosteroid APIs, leveraging its 9β,11β-epoxide and 16β-methyl groups for targeted therapeutic effects.
• Research & Development: Serves as a valuable reference standard and building block in medicinal chemistry research for developing new steroidal compounds with modified biological profiles.
• Process Chemistry: Employed in scale-up and optimization studies for the commercial manufacturing of steroid-based pharmaceuticals.
• Fine Chemical Production: Utilized in the synthesis of other specialized, high-value steroidal derivatives for various applications.

Basic Information

Product Name	9β,11β-Epoxy-17,21-Dihydroxy-16β-Methylpregna-1,4-Diene-3,20-Dione
CAS No.	981-34-0
Molecular Formula	C22H28O6
Molecular Weight	388.46 g/mol
Synonyms	9β,11β-Epoxy-16β-methylprednisolone; 16β-Methyl-9β,11β-epoxyprednisolone; 9β,11β-Epoxy-16β-methyl-1,4-pregnadiene-17α,21-diol-3,20-dione; (9β,11β)-16β-Methyl-9,11-epoxypregna-1,4-diene-17α,21-diol-3,20-dione; 16β-Methyl-9β,11β-oxidoprednisolone; Betamethasone 9,11-Epoxide Intermediate; NSC 104801
EINECS	Contact for details

Quality Control

Our 9β,11β-Epoxy-17,21-Dihydroxy-16β-Methylpregna-1,4-Diene-3,20-Dione is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for pharmaceutical applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We support compliance with cGMP and ICH guidelines, and specifications can be aligned with client-specific pharmacopeial requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to prevent moisture absorption, which may affect stability and handling properties. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0% Any single impurity ≤0.5%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.