Description

Brompheniramine Hydrogen Maleate is the hydrogen maleate salt form of the first-generation alkylamine antihistamine, brompheniramine. This compound is a critical active pharmaceutical ingredient (API) valued for its potent H1-receptor antagonism, which effectively blocks histamine activity. It is primarily required by pharmaceutical manufacturers for the formulation of oral and injectable medications targeting allergic conditions, such as hay fever, rhinitis, and urticaria. Its reliable efficacy makes it a cornerstone in both prescription and over-the-counter (OTC) anti-allergy therapeutics.

Application

• Pharmaceutical API: Primary use as the active ingredient in anti-allergy tablet, capsule, and syrup formulations.
• Injectable Solutions: Used in parenteral preparations for rapid relief of severe allergic reactions.
• Combination Cold & Flu Medications: A key component in multi-symptom relief products combined with analgesics, decongestants, and antitussives.
• Veterinary Pharmaceuticals: Formulated for the treatment of allergic responses in companion animals.
• Research & Development: Serves as a reference standard and building block in pharmacological and medicinal chemistry research.
• Controlled-Release Formulations: Incorporated into advanced drug delivery systems for prolonged therapeutic effect.

Basic Information

Item	Details
Product Name	Brompheniramine Hydrogen Maleate
CAS No.	980-71-2
Molecular Formula	C20H23BrN2O4
Molecular Weight	435.31 g/mol
Synonyms	Brompheniramine Maleate; Brompheniramine Acid Maleate; 2-[4-Bromo-α-(2-dimethylaminoethyl)benzyl]pyridine maleate (1:1); Parabromdylamine Maleate; Dimegan; Ilvin; Veltane; Dimotane
EINECS	213-563-5

Quality Control

Our Brompheniramine Hydrogen Maleate is manufactured under strict quality management systems. It is produced to meet exacting standards, including USP-NF and Pharmaceutical Grade specifications, ensuring suitability for human pharmaceutical applications. Every batch undergoes comprehensive analytical testing, including assay, impurity profiling, and residual solvent analysis. A Certificate of Analysis (COA) documenting full compliance is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a low-humidity environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to standard
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	98.0% - 102.0% (on anhydrous basis)
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 1.0%; Any single impurity ≤ 0.5%
Specific Rotation	Contact for details
Melting Point	130°C - 135°C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.