Description

3-(3-Iodophenyl)-1,1,1-Trifluoro-2-Propanone is a high-purity fluorinated and iodinated aromatic ketone building block. This compound is valued for its unique molecular architecture, which combines a trifluoromethyl ketone moiety with an iodophenyl group, making it a versatile intermediate in advanced synthetic chemistry. It is primarily sought after by researchers and process chemists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new drug candidates, particularly for molecules targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the creation of advanced herbicides and fungicides, where the trifluoromethyl and iodine groups can enhance biological activity and environmental stability.
• Material Science Precursor: Serves as a building block for specialty polymers and liquid crystals, where its specific halogen and fluorine content modifies material properties.
• Cross-Coupling Reactions: The iodine atom makes it an excellent substrate for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Sonogashira) to create complex biaryl structures.
• Fluorine Chemistry Research: An important reagent for studying the effects of fluorine substitution on reactivity and physicochemical properties in organic molecules.
• Radiolabeling Precursor: The iodine-127 isotope provides a stable analog for developing protocols that can be adapted for radioactive iodine-123 or iodine-131 labeling in diagnostic and therapeutic agents.

Basic Information

Product Name	3-(3-Iodophenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	898787-67-2
Molecular Formula	C9H6F3IO
Molecular Weight	314.04 g/mol
Synonyms	1-[3-(Trifluoroacetyl)phenyl]iodide; 3'-Iodo-α,α,α-trifluoroacetophenone; 3-Iodophenyl trifluoromethyl ketone; 1-(3-Iodophenyl)-2,2,2-trifluoroethanone; 3-Iodo-α,α,α-trifluoroacetophenone; m-Iodophenyl trifluoromethyl ketone; 3-(3-Iodophenyl)-1,1,1-trifluoropropan-2-one; TFPI
EINECS	Contact for details

Quality Control

Our production of 3-(3-Iodophenyl)-1,1,1-Trifluoro-2-Propanone adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and IR for structural confirmation, and GC-MS for impurity profiling. We provide detailed Certificates of Analysis (COA) with each shipment, ensuring traceability and compliance with your research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and potential decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.