Description

3-(2-Fluorophenyl)-1,1,1-Trifluoro-2-Propanone is a high-value fluorinated aromatic ketone building block, prized for its unique reactivity profile and the introduction of fluorine atoms into target molecules. This compound is essential for advanced organic synthesis, particularly in the development of pharmaceuticals and agrochemicals where fluorine substitution is critical for enhancing metabolic stability, bioavailability, and binding affinity. It serves as a key intermediate for researchers and manufacturers in fine chemical, pharmaceutical R&D, and material science sectors requiring precise fluorination.

Application

• Pharmaceutical Intermediate: A crucial precursor in the synthesis of active pharmaceutical ingredients (APIs), especially for molecules containing a trifluoromethyl ketone or fluorinated aryl motifs.
• Agrochemical Synthesis: Used in the development of advanced herbicides, fungicides, and pesticides where fluorine atoms improve product efficacy and environmental profile.
• Ligand and Catalyst Development: Serves as a building block for creating specialized ligands and organocatalysts used in asymmetric synthesis and transition metal catalysis.
• Material Science Research: Employed in the synthesis of fluorinated polymers, liquid crystals, and organic electronic materials to modify physical properties.
• Fluorine Chemistry Research: A valuable substrate for studying novel fluorination reactions and developing new methodologies in synthetic organic chemistry.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for the production of client-specific target molecules.

Basic Information

Product Name	3-(2-Fluorophenyl)-1,1,1-Trifluoro-2-Propanone
CAS No.	898787-53-6
Molecular Formula	C9H6F4O
Molecular Weight	206.14 g/mol
Synonyms	1,1,1-Trifluoro-3-(2-fluorophenyl)propan-2-one; 2-Fluorophenyl trifluoromethyl ketone; 2'-Fluoro-α,α,α-trifluoroacetophenone; 3-(2-Fluorophenyl)-1,1,1-trifluoropropan-2-one; 2-Fluoro-α,α,α-trifluoroacetophenone; 1-(2-Fluorophenyl)-3,3,3-trifluoropropan-2-one; α,α,α-Trifluoro-2'-fluoroacetophenone; TFAP-2F
EINECS	Contact for details

Quality Control

Our 3-(2-Fluorophenyl)-1,1,1-Trifluoro-2-Propanone is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and commercial synthesis. We provide comprehensive analytical data, including HPLC/GC purity, NMR, and mass spectrometry confirmation. A Certificate of Analysis (COA) detailing all specifications is available with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber glass or compatible opaque material.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.