Description

2-(3-Cyanophenyl)-2'-Trifluoromethylacetophenone is a high-purity, advanced pharmaceutical intermediate characterized by its distinct aromatic ketone structure with cyano and trifluoromethyl functional groups. This compound is critical for the synthesis of complex active pharmaceutical ingredients (APIs), particularly those targeting central nervous system and metabolic disorders, due to its role as a key building block. It is essential for R&D laboratories and production facilities in the pharmaceutical and fine chemical industries seeking reliable, high-quality intermediates for innovative drug development and scale-up processes.

Application

• Pharmaceutical Intermediate: A crucial building block in the multi-step synthesis of novel Active Pharmaceutical Ingredients (APIs), especially for CNS and metabolic disease targets.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging the biological activity of the trifluoromethyl group.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and advanced organic materials with specific electronic or optical properties.
• Organic Synthesis & Catalysis: Employed in academic and industrial research for constructing complex molecular architectures and studying new catalytic reactions.
• Ligand and Receptor Studies: Utilized in medicinal chemistry for the design and synthesis of molecular probes to study enzyme inhibition and receptor binding.

Basic Information

Product Name	2-(3-Cyanophenyl)-2'-Trifluoromethylacetophenone
CAS No.	898784-51-5
Molecular Formula	C16H10F3NO
Molecular Weight	289.26 g/mol
Synonyms	2-(3-Cyanophenyl)-2'-(trifluoromethyl)acetophenone; 1-[3-Cyanophenyl]-2-[2-(trifluoromethyl)phenyl]ethanone; 2-(3-Cyanophenyl)-1-(2-(trifluoromethyl)phenyl)ethan-1-one; 3-Cyano-2'-trifluoromethyl desoxybenzoin; α-(3-Cyanophenyl)-α'-(trifluoromethyl)acetophenone; Ketone, (3-cyanophenyl)[2-(trifluoromethyl)phenyl]methyl; CAS 898784-51-5
EINECS	Contact for details

Quality Control

Every batch of 2-(3-Cyanophenyl)-2'-Trifluoromethylacetophenone is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure it meets the highest standards of purity and consistency. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates. A detailed Certificate of Analysis (COA), providing batch-specific data for identity, purity, and impurity profiles, is provided with each shipment and is available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from incompatible materials such as strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.