Description

2'-Chloro-4'-Fluoro-3-(4-Fluorophenyl)Propiophenone is a high-value fluorinated aromatic ketone intermediate, recognized for its precise molecular architecture. This compound is critical for synthesizing complex active pharmaceutical ingredients (APIs) and advanced organic materials where specific halogen substitution patterns are required. It is primarily sought by research institutions and manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for developing new therapeutic agents and high-performance materials.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders and anti-inflammatory applications.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides, leveraging its fluorinated structure for enhanced bioactivity and stability.
• Material Science Research: Serves as a precursor for liquid crystals, organic semiconductors, and other advanced polymeric materials requiring specific electronic properties.
• Chemical Research & Development: A versatile scaffold for medicinal chemistry, enabling structure-activity relationship (SAR) studies and the creation of compound libraries.
• Custom Synthesis: Employed by contract research and manufacturing organizations (CROs/CMOs) for the bespoke production of complex molecules for client projects.

Basic Information

Product Name	2'-Chloro-4'-Fluoro-3-(4-Fluorophenyl)Propiophenone
CAS No.	898768-62-2
Molecular Formula	C15H11ClF2O
Molecular Weight	280.70 g/mol
Synonyms	1-(2-Chloro-4-fluorophenyl)-3-(4-fluorophenyl)propan-1-one; 3-(4-Fluorophenyl)-1-(2-chloro-4-fluorophenyl)propan-1-one; 2-Chloro-4-fluoro-3-(4-fluorophenyl)propiophenone; 898768-62-2; Propiophenone, 2'-chloro-4'-fluoro-3-(4-fluorophenyl)-; 1-Propanone, 1-(2-chloro-4-fluorophenyl)-3-(4-fluorophenyl)-
EINECS	Contact for details

Quality Control

Our production of 2'-Chloro-4'-Fluoro-3-(4-Fluorophenyl)Propiophenone adheres to stringent quality management protocols to ensure batch-to-batch consistency and high purity. Each lot is analyzed using advanced chromatographic and spectroscopic techniques (HPLC, GC, NMR, IR) to verify identity, potency, and impurity profiles. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality system is designed to support cGMP (current Good Manufacturing Practice) standards for pharmaceutical intermediate applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials such as strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single unknown impurity ≤ 0.5%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.