Description

3'-Fluoro-[1,1'-Biphenyl] -4-Acetonitrile is a high-purity fluorinated biphenyl derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a versatile aromatic scaffold with a strategically placed fluorine atom and a reactive nitrile group, enabling precise molecular construction. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially in kinase inhibitor and CNS-active compound research.
• Agrochemical Synthesis: Used to construct advanced herbicides and fungicides, leveraging the fluorine atom for enhanced bioactivity and metabolic stability.
• Liquid Crystal & OLED Material Development: Serves as a core unit for creating fluorinated aromatic components in electronic display and lighting materials.
• Cross-Coupling Reactions: An excellent substrate for Suzuki, Stille, and other palladium-catalyzed coupling reactions to create complex biaryl systems.
• Functional Material Research: Employed in the development of organic semiconductors, sensors, and specialty polymers.
• Nitrile Transformation Chemistry: The nitrile group can be converted into amides, acids, amines, and tetrazoles, expanding its utility in library synthesis.

Basic Information

Item	Detail
Product Name	3'-Fluoro-[1,1'-Biphenyl] -4-Acetonitrile
CAS No.	893734-08-2
Molecular Formula	C14H10FN
Molecular Weight	211.24 g/mol
Synonyms	4-(3-Fluorobiphenyl-4-yl)acetonitrile; (3'-Fluoro[1,1'-biphenyl]-4-yl)acetonitrile; 3'-Fluoro-4-biphenylacetonitrile; 3-Fluoro-4'-cyanobiphenyl; 4-(3-Fluorophenyl)benzenacetonitrile; p-(3-Fluorophenyl)phenylacetonitrile; [1,1'-Biphenyl]-4-acetonitrile, 3'-fluoro-
EINECS	Contact for details

Quality Control

Every batch of 3'-Fluoro-[1,1'-Biphenyl] -4-Acetonitrile is produced and tested under a strict quality management system to ensure high purity and batch-to-batch consistency. Our standard grade typically meets a purity specification of ≥97% (by HPLC), with comprehensive control of related substances. A detailed Certificate of Analysis (COA) documenting identity, purity, and impurity profile is provided with each shipment. We support development and scale-up with customized specifications to meet specific project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed to exclude moisture and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.