Description

Benzonitrile, 5-Amino-4-Bromo-2-Fluoro is a high-purity, multi-functional halogenated aromatic nitrile building block of significant importance in advanced organic synthesis. Its unique substitution pattern makes it a versatile intermediate for constructing complex molecular architectures, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. This compound is primarily sought by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel compounds with targeted biological activity.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, especially those targeting central nervous system (CNS) disorders, oncology, and anti-infective therapies.
• Agrochemical Synthesis: Used to build advanced herbicide and pesticide molecules, leveraging the fluorine and bromine atoms for enhanced biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a starting material for creating specialized ligands used in transition metal catalysis and asymmetric synthesis.
• Material Science Research: Employed in the development of organic electronic materials, liquid crystals, and advanced polymers due to its aromatic core and polar nitrile group.
• Custom Synthesis and Contract Manufacturing: A critical building block for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.
• Academic and Industrial R&D: Utilized in research laboratories for methodological studies in cross-coupling reactions, nucleophilic aromatic substitution, and fluorination chemistry.

Basic Information

Product Name	Benzonitrile, 5-Amino-4-Bromo-2-Fluoro
CAS No.	893615-28-6
Molecular Formula	C7H4BrFN2
Molecular Weight	215.02 g/mol
Synonyms	5-Amino-4-bromo-2-fluorobenzonitrile; 4-Bromo-5-amino-2-fluorobenzonitrile; 2-Fluoro-5-amino-4-bromobenzonitrile; 4-Bromo-2-fluoro-5-aminobenzonitrile; 5-Amino-4-bromo-2-fluorophenyl cyanide; Benzonitrile, 2-fluoro-5-amino-4-bromo-; (5-Amino-4-bromo-2-fluorophenyl)carbonitrile
EINECS	Contact for details

Quality Control

Every batch of 5-Amino-4-Bromo-2-Fluorobenzonitrile is produced under a strict quality management system and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. Our standard quality commitment includes HPLC purity ≥98% (with higher grades available), full spectroscopic characterization (NMR, IR, MS), and control of specified impurities. A detailed Certificate of Analysis (COA) is provided with each shipment, and we support customer audits and regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.