Description

4-Amino-5-Chloro-2-(Trifluoromethyl)Benzonitrile is a high-value, multi-functional aromatic intermediate characterized by its unique trifluoromethyl and nitrile substituents. This compound matters for its role as a critical building block in the synthesis of advanced pharmaceutical agents and agrochemicals, where its specific substitution pattern imparts desirable biological activity and metabolic stability. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) drugs, kinase inhibitors, and anti-infective agents.
• Agrochemical Synthesis: Building block for developing new generation herbicides, fungicides, and insecticides, leveraging the bioactivity of the trifluoromethyl group.
• Ligand and Catalyst Development: Used in organometallic chemistry to create specialized ligands for catalysis and material science applications.
• Functional Material Research: Serves as a monomer or modifier in the development of advanced polymers, liquid crystals, and electronic materials.
• Organic Synthesis Scaffold: Versatile starting material for further functionalization (e.g., amide formation, cyclization) to create diverse chemical libraries for screening.

Basic Information

Product Name	4-Amino-5-Chloro-2-(Trifluoromethyl)Benzonitrile
CAS No.	888073-09-4
Molecular Formula	C8H4ClF3N2
Molecular Weight	220.58 g/mol
Synonyms	5-Chloro-4-amino-2-(trifluoromethyl)benzonitrile; 2-Amino-6-chloro-α,α,α-trifluoro-m-tolunitrile; 4-Amino-5-chloro-α,α,α-trifluoro-o-tolunitrile; 5-Chloro-2-(trifluoromethyl)-4-aminobenzonitrile; 4-Amino-5-chloro-2-trifluoromethylbenzonitrile; 2-Cyano-5-chloro-4-amino-α,α,α-trifluorotoluene; 4-Amino-α,α,α,5-chloro-2-trifluoromethylbenzonitrile
EINECS	Contact for details

Quality Control

Our 4-Amino-5-Chloro-2-(Trifluoromethyl)Benzonitrile is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical specifications. Our quality commitment aligns with cGMP principles where applicable, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.