Description

Tosyl-Propargyl-Triethylene Glycol is a specialized bifunctional chemical building block featuring both a tosylate leaving group and a terminal alkyne. This unique structure makes it a valuable intermediate for click chemistry, particularly in the synthesis of complex molecular architectures via copper-catalyzed azide-alkyne cycloaddition (CuAAC). It is essential for researchers and manufacturers in pharmaceutical development, materials science, and bioconjugation who require precise, modular, and efficient coupling strategies to create advanced polymers, probes, and drug-linker systems.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing antibody-drug conjugates (ADCs) and other targeted therapeutics via click chemistry.
• Polymer & Materials Science: Used as a functional monomer or cross-linker to introduce alkyne handles into polymers, hydrogels, and dendritic structures.
• Bioconjugation & Probe Synthesis: Facilitates the labeling of biomolecules (proteins, peptides, nucleic acids) with fluorescent dyes, affinity tags, or other functional modules.
• Chemical Biology Tool: Enables the study of biomolecular interactions and cellular processes through bioorthogonal labeling strategies.
• Surface Functionalization: Applied to modify surfaces (e.g., chips, nanoparticles, beads) with alkyne groups for subsequent immobilization of azide-bearing molecules.
• Ligand & Catalyst Development: Serves as a precursor for creating specialized ligands and catalysts with tailored spacer arms and reactivity.

Basic Information

Product Name	Tosyl-Propargyl-Triethylene Glycol
CAS No.	888009-94-7
Molecular Formula	C₁₈H₂₆O₆S
Molecular Weight	370.46 g/mol
Synonyms	Propargyl-PEG3-Tosylate; 2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate; Triethylene Glycol Monopropargyl Monotosylate; Tosyl-PEG3-Propargyl; 4-Methylbenzenesulfonic Acid 2-[2-[2-(2-Propyn-1-yloxy)ethoxy]ethoxy]ethyl Ester; Propargyl-O3-Ts; PEG3-Propargyl Tosylate
EINECS	Contact for details

Quality Control

Our Tosyl-Propargyl-Triethylene Glycol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and Karl Fischer titration for water content, to ensure it meets the high standards required for research and production. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability, consistency, and compliance with your specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). The compound is moisture-sensitive; keep the original container sealed under an inert atmosphere (e.g., nitrogen or argon) for long-term stability.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.