Description

Cholesteryl Tosylate is a versatile organic intermediate derived from cholesterol, where the hydroxyl group is esterified with p-toluenesulfonyl chloride. This modification creates a valuable leaving group, making it a critical reagent in synthetic organic chemistry for the controlled functionalization of steroidal frameworks. It is primarily sought after by research institutions and pharmaceutical companies engaged in the development of novel bioactive compounds, liquid crystals, and advanced materials.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of modified steroids, prodrugs, and other pharmacologically active molecules.
• Liquid Crystal Research: Serves as a precursor in the development of cholesteric liquid crystals for display technologies and optical devices.
• Chemical Synthesis: Used as an activated ester in nucleophilic substitution reactions to introduce the cholesterol moiety into complex molecular architectures.
• Material Science: Employed in the creation of functionalized polymers and surfactants with specific self-assembly properties.
• Bioconjugation: Facilitates the attachment of cholesterol tags to peptides, proteins, or other biomolecules for studies on membrane interactions and drug delivery.

Basic Information

Product Name	Cholesteryl Tosylate
CAS No.	1182-65-6
Molecular Formula	C34H52O3S
Molecular Weight	540.85 g/mol
Synonyms	Cholesteryl p-Toluenesulfonate; 5-Cholesten-3β-yl p-Toluenesulfonate; 3β-Cholest-5-en-3-yl p-Toluenesulfonate; Cholesterol Tosylate; Cholesterol p-Toluenesulfonate Ester; Tosylcholesterol; Cholesteryl Tosylate Ester; Cholesteryl 4-Methylbenzenesulfonate
EINECS	214-647-7

Quality Control

Our Cholesteryl Tosylate is manufactured under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods, to ensure it meets the high standards required for research and development applications. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Melting Point	118°C - 122°C
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.