Description

Benzyl (R)-2-Tosyloxypropionate is a high-value chiral intermediate and protecting group reagent, specifically the (R)-enantiomer. This compound matters for its critical role in the stereoselective synthesis of active pharmaceutical ingredients (APIs) and fine chemicals, where precise chirality is essential for biological activity. It is primarily needed by pharmaceutical R&D laboratories, process chemists, and manufacturers of specialty agrochemicals and advanced materials who require enantiomerically pure building blocks.

Application

• Chiral Intermediate in Pharmaceutical Synthesis: A key building block for the preparation of enantiomerically pure drugs, particularly in the synthesis of β-lactam antibiotics and other chiral active pharmaceutical ingredients (APIs).
• Asymmetric Synthesis Reagent: Used in stereocontrolled chemical reactions to introduce the (R)-configured propionate moiety into complex molecular frameworks.
• Protecting Group Chemistry: The benzyl ester and tosylate groups can serve as protective functionalities for carboxylic acids and alcohols, respectively, in multi-step synthetic sequences.
• Agrochemical Intermediate: Employed in the research and production of chiral pesticides and herbicides where specific stereochemistry impacts efficacy and environmental profile.
• Material Science Research: Utilized in the development of chiral polymers, liquid crystals, and other advanced functional materials.
• Academic & Industrial R&D: A valuable reagent for method development in organic chemistry and catalysis studies within university and corporate research laboratories.

Basic Information

Product Name	Benzyl (R)-2-Tosyloxypropionate
CAS No.	117589-36-3
Molecular Formula	C17H18O5S
Molecular Weight	334.39 g/mol
Synonyms	(R)-Benzyl 2-((4-methylphenyl)sulfonyloxy)propanoate; (R)-Benzyl 2-(p-toluenesulfonyloxy)propionate; (R)-Benzyl 2-Tosyloxypropanoate; D-(-)-Benzyl 2-Tosyloxypropionate; (R)-(-)-Benzyl 2-Tosyloxypropionate; Propanoic acid, 2-[(4-methylphenyl)sulfonyl]oxy]-, phenylmethyl ester, (2R)-; Benzyl (R)-(-)-2-(p-Toluenesulfonyloxy)propionate
EINECS	Contact for details

Quality Control

Our Benzyl (R)-2-Tosyloxypropionate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure compliance with stringent industry standards for chiral intermediates. Certificates of Analysis (COA) detailing identity, purity, enantiomeric excess (ee), and impurity profiles are available upon request to support your quality and regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at controlled room temperature (15-25°C). Keep the container tightly sealed in a dry environment to maintain product integrity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.